Manufacturing Supervisor, NGS TE Production

Twist Bioscience Corporation; South San Francisco (CA); On-site; USD 62,000 - 69,000; Full time

Job summary

Twist Bioscience Corporation seeks a Manufacturing Supervisor for NGS TE Production in South San Francisco, CA. You will train and lead staff in high‑throughput molecular workflows, ensure SOP adherence, and drive continuous process improvement in a LEAN, GMP/ISO‑aligned setting.

You will oversee batch records, calibrate equipment, and coordinate shift activities while maintaining 5S and safety standards. Strong molecular biology skills and leadership are essential.

Qualifications

• Minimum 5 years of lab experience in a manufacturing environment.
• A.S. or B.S. in Biology, Chemistry, or Biochemistry.
• Experience operating liquid handlers such as Hamilton and Tecan.
• Experience with instrumentation for PCR, cell-based cloning, miniprep extraction, and purification is a huge plus.
• Experience with sample tracking software and with interfaces between robotic instrumentation and LIMS/MES systems.
• Experience working in ISO, GMP, and LEAN manufacturing environments and applying lean manufacturing concepts.
• Excellent scientific computation and data analysis skills.
• Experience leading small teams in a laboratory environment.

Responsibilities

• Manufacture high-quality gene products in a high-throughput lab according to SOPs.
• Document thoroughly in batch records and databases, including problems and deviations.
• Operate semi-automated and automated lab equipment for molecular workflows.
• Track product quality using physical and functional tests.
• Troubleshoot test results and apply scientific problem-solving.
• Lead shift pass-downs and prioritize workflows.

Skills

Lab leadership

Lean manufacturing

GMP/ISO knowledge

PCR & cloning

LIMS/MES interfaces

Data analysis

Education

Biology/Chemistry/Biochemistry degree

Tools

Hamilton

Tecan

Job description

Manufacturing Supervisor, NGS TE Production

USA - South San Francisco, CA

The Manufacturing Supervisor, NGS TE Production will bring strong knowledge of synthetic and molecular biology techniques, including PCR, vector production, cloning, miniprep, DNA analysis, sequencing, and packaging. In this role, you’ll perform, train, and oversee production staff on molecular biology workflows in a highly automated, high-throughput environment, and you’ll be responsible for manufacturing and analyzing a variety of custom gene products across Twist Bioscience’s proprietary workflow according to SOPs and the daily production schedule.

As the main point of contact for shift operators, you’ll make sure the shift team is working to the plan of record, provide guidance, set priorities, and lead troubleshooting. You’ll also lead the pass-down of information between shifts.

The ideal candidate works independently, is highly organized, has excellent molecular biology skills, maintains and builds 5S systems, contributes to process improvement and documentation, and communicates effectively with peers and management. You’ll have knowledge of good laboratory practices (GLPs), familiarity with GMP or ISO-rated production, and experience leading and training others. You must be comfortable working in a LEAN manufacturing, controlled laboratory environment.

Shift 2B: Wednesday-Friday w/alt Saturday 7:00pm-7:30am What You’ll Be Doing

• Manufacture high-quality custom gene products in a high-throughput manufacturing lab according to established SOPs
• Maintain thorough, accurate, and detailed documentation of all work in batch records, databases, or other approved formats, including problems and deviations
• Operate semi-automated and automated lab equipment for molecular biology workflows
• Track metrics on product quality using both physical and functional test methods
• Apply scientific principles to problem-solve and troubleshoot test results
• Proactively identify production problems and recommend solutions for lab techniques, protocols, processes, and product and equipment handling
• Uphold standards defined by the manufacturing process
• Support continuous cost and process improvement initiatives
• Work safely at all times
• Maintain and calibrate select lab equipment
• Lead shift pass-down efforts and prioritize workflows
• Take accountability for the shift when senior personnel are not on site
• Advise on meeting schedules and resolving technical problems, and provide production guidance to junior manufacturing staff
• Schedule staff
• Review and verify production batch records and manufacturing documents
• Write and submit incident reports, CAPAs, planned deviations, and related documentation
• Follow regulatory and ISO 13485 requirements

What You’ll Bring to the Team

• A.S. or B.S. in Biology, Chemistry, or Biochemistry
• Minimum of 5 years of lab experience in a manufacturing environment
• Experience operating liquid handlers such as Hamilton and Tecan
• Experience with instrumentation for PCR, cell-based cloning, miniprep extraction, and purification is a huge plus
• Experience with sample tracking software and with interfaces between robotic instrumentation and LIMS/MES systems
• Experience working in ISO, GMP, and LEAN manufacturing environments and applying lean manufacturing concepts
• Excellent scientific computation and data analysis skills
• Experience assessing current processes and techniques and implementing procedural improvements
• Experience leading small teams in a laboratory environment
• Strong problem-solving and communication skills
• Ability to stand for long periods while performing duties
• Ability to work safely with chemicals and hazardous materials
• Ability to lift up to 20 lbs
• Ability to work outside regular hours or a flexible shift as needed

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as "writing" DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

$45 - $50 USD

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Twist Bioscience’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.