Manufacturing Lead, IgG Production

Twist Bioscience Corporation; Wilsonville (OR); Presencial; USD 85.000 - 105.000; Jornada completa

Descripción de la vacante

Twist Bioscience Corporation seeks a Manufacturing Lead to oversee production and analysis of gene products across a proprietary workflow, maintaining schedule and quality. You will guide shift associates, troubleshoot processes, and perform manufacturing tasks while upholding SOPs and batch records.

The role emphasizes hands-on lab work, documentation, and cross-functional collaboration to keep fast-paced production on track in a growing biotech environment.

Formación

• Bachelors/Associates degree in biology, chemistry, biochemistry; degree preferred but relevant lab experience considered.
• Familiarity or prior experience in a manufacturing environment.
• Good written and verbal skills.
• Proficient computer skills; experience with Excel, Word, Jira/Confluence.

Responsabilidades

• Assist the production supervisor and guide the work on the manufacturing floor.
• Troubleshoot processes and instrumentation related to manufacturing.
• Take responsibility for daily operations when the supervisor is unavailable.
• Maintain daily operations, equipment maintenance, fulfill production requests, and reviews.
• Train new laboratory manufacturing associates.
• Manufacture high-quality oligo products following SOPs.
• Operate lab equipment and liquid handling robots.
• Document work thoroughly using templates; update instructions.
• Follow lean manufacturing, ISO and GMP practices.

Conocimientos

Team leadership

Troubleshooting

Documentation

Data analysis

Attention to detail

Safety and GMP practices

Educación

Bachelor's or Associate degree in biology/chemistry/biochemistry

Herramientas

Jira/Confluence

Excel

Descripción del empleo

The Manufacturing Lead will be responsible for the manufacturing and analysis of a variety of gene products across Twist Bioscience’s proprietary process workflow to meet the Twist production forecast and timelines. The Manufacturing Lead will be held accountable for maintaining production schedule and troubleshooting, guiding the work of other shift associates while also performing manufacturing tasks. Activities will include but not be limited to: operating a variety of laboratory equipment including liquid handling robots, maintaining detailed documentation, cleaning and restocking the lab, and practicing good lab bench techniques to ensure high quality and consistent products.

The ideal candidate will be driven and will do what it takes to keep manufacturing on track in a fast paced start-up environment. The Manufacturing Lead will also be responsible for the production of genes and various intermediates according to established SOPs and complete manufacturing batch records to contribute to the daily production schedule.

What You’ll Be Doing

• Assisting the production supervisor and guiding the work performed on the manufacturing floor by manufacturing associates.
• Troubleshooting all processes related to manufacturing process and instrumentation.
• Taking responsibility for daily operations when the supervisor is not available.
• Maintaining daily operations w/ or w/o the supervisor (equipment maintenance, fulfill production request, retain review)
• Reviewing time sensitive material and calendar events.
• Overseeing material inventory and waste management activities for the shift.
• Monitoring the flow of intermediate products through the Manufacturing Execution System (MES) and notifying the supervisor of any discrepancies.
• Reviewing JIRA tickets with supervisor to create action items.
• Enforcing checklist and auditing activities which are built into the production process.
• Training new laboratory manufacturing associates.
• Working in the laboratory and performing any process tasks.
• Manufacturing high quality custom oligo containing products in a high throughput MFG lab according to established SOPs.
• Operating laboratory equipment and liquid handling robots (Hamilton Stars, centrifuges, sealers, thermocyclers, spectrometers, Illumina Next-Gen sequencers etc.)
• Effectively using molecular and cell biology processes and techniques, especially PCR, DNA quantitation, purification and cloning.
• Maintain thorough, accurate and detailed documentation of all work performed using existing document templates and applications.
• Updating and writing work instructions and documentation.
• Working independently and in a safe manner.
• Paying great attention to detail and yielding consistent results.
• Performing troubleshooting and handling process deviations correctly.
• Analyzing data outcomes from manufacturing steps and deciding on or recommending a course of action.
• Following lean manufacturing, ISO and GMP practices.

What You’ll Bring to the Team

• Bachelors/Associates degree in biology, chemistry, biochemistry: degree preferred but will consider candidates with relevant laboratory experience
• Familiarity or prior experience in a manufacturing environment
• Good written and verbal skills
• Good computer skills and comfort in using computers for all aspects of MFG, experience with excel and word, Jira/Confluence, web based or similar programs

Physical Requirements

• Ability to work in a controlled laboratory environment
• Must be able to stand for long periods of time while performing duties
• Must be able to work safely with chemicals and hazardous materials
• Must be able to lift up to 20 lbs
• Must have flexibility to work outside of regular work hours/work a flexible shift as needed

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Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Twist Bioscience’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.