Sr Bioinformatics Scientist

Twist Bioscience Corporation; South San Francisco (CA); On-site; USD 135,000 - 173,000; Full time

Benefits offered by this job

Bonus

Equity

Benefits

Job summary

Twist Bioscience Corporation seeks a Senior Bioinformatics Scientist to join the Scientific Computing team, developing computational methods and predictive models to interpret biological data and guide product development. You will collaborate across sequencing, DNA synthesis, and protein solutions, building workflows and evaluating methods to improve experimental outcomes.

Strong computational skills and scientific judgment are essential for translating open-ended questions into actionable

Qualifications

• Ph.D. with 3+ years, or Master’s 6+ years, in bioinformatics or related field.
• Strong Python programming skills and NGS data experience.
• Experience building reproducible workflows with Nextflow.
• Ability to develop and evaluate computational algorithms and models.
• Solid statistics, experimental design, and critical interpretation of results.
• Ability to collaborate with experimental scientists and explain complex findings.

Responsibilities

• Develop novel computational methods and algorithms supporting DNA synthesis, sequence analysis, and protein characterization.
• Partner with experimental scientists to formulate hypotheses, design experiments, and interpret results that guide product and process development.
• Analyze NGS and other experimental datasets to identify biological patterns, understand sources of variability, and investigate unexpected outcomes.
• Apply statistical methods, machine learning, and predictive modeling to connect sequence and experimental features with product quality and performance.
• Evaluate and validate analytical approaches, including their accuracy, limitations, and applicability across experimental conditions.
• Develop reproducible analysis pipelines using Nextflow and other scientific computing tools to support research and method evaluation.
• Communicate findings and recommendations to scientific and cross-functional stakeholders, and collaborate with engineers to translate successful methods into broader use.
• Explore new technologies and analytical approaches as research priorities evolve.

Skills

Python programming

NGS analysis

Statistics & experimental design

Machine learning

Reproducible analysis workflows

Communication with scientists

Education

Ph.D. in bioinformatics / computational biology

Master's degree in a related field

Bachelor's degree or equivalent experience

Tools

Nextflow

Job description

Twist Bioscience is seeking a Senior Bioinformatics Scientist to join our Scientific Computing team supporting R&D across DNA Synthesis and Protein Solutions. You will develop computational methods and predictive models to understand biological and experimental data, guide product development, and improve scientific workflows.

Working at the intersection of computational and experimental biology, you will partner with scientists to investigate challenging questions across sequencing, DNA synthesis, and protein characterization. Your work will include developing algorithms, testing hypotheses, evaluating new methods, and building reproducible analysis workflows.

We are looking for a curious scientist with strong computational skills and sound scientific judgment who enjoys learning new biology and turning open-ended questions into actionable insights.

Key Responsibilities

• Develop novel computational methods and algorithms supporting DNA synthesis, sequence analysis, and protein characterization.
• Partner with experimental scientists to formulate hypotheses, design experiments, and interpret results that guide product and process development.
• Analyze NGS and other experimental datasets to identify biological patterns, understand sources of variability, and investigate unexpected outcomes.
• Apply statistical methods, machine learning, and predictive modeling to connect sequence and experimental features with product quality and performance.
• Evaluate and validate analytical approaches, including their accuracy, limitations, and applicability across experimental conditions.
• Develop reproducible analysis pipelines using Nextflow and other scientific computing tools to support research and method evaluation.
• Communicate findings and recommendations to scientific and cross-functional stakeholders, and collaborate with engineers to translate successful methods into broader use.
• Explore new technologies and analytical approaches as research priorities evolve.

Required Qualifications

• Ph.D. with 3+ years, Master’s degree with 6+ years, or Bachelor’s degree with 8+ years of relevant experience in bioinformatics, computational biology, biostatistics, or a related field; equivalent combinations of education and experience will be considered.
• Strong Python programming skills and experience analyzing biological or experimental data.
• Hands-on experience with NGS analysis and a solid understanding of molecular biology.
• Experience developing and evaluating computational algorithms, statistical methods, or predictive models.
• Strong foundation in statistics, experimental design, and critical interpretation of scientific results.
• Experience building reproducible analysis workflows using Nextflow or a comparable tool.
• Demonstrated ability to independently investigate scientific problems and learn unfamiliar methods or biological domains.
• Ability to collaborate closely with experimental scientists and communicate complex findings clearly.

Preferred Qualifications

• Experience with protein data analysis, DNA synthesis, or sequence design.
• Experience applying machine learning to biological data, including rigorous validation.
• Experience working with high-throughput experimental datasets and integrating multiple data types.
• Familiarity with cloud computing and scalable scientific workflows.
• A track record of developing computational methods that inform experimental decisions or improve products.

We welcome candidates with depth in a relevant scientific area and the curiosity and quantitative foundation to contribute across disciplines.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as "writing" DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

$135,000 - $173,000 USD

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Twist Bioscience's Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.