Upstream Bioprocess Scientist - Lentiviral & Bioreactor Dev

Johnson & Johnson Innovative Medicine; Spring House (PA); On-site; USD 110,000 - 150,000; Full time

Job summary

Johnson & Johnson is seeking a Scientist, Upstream Process Development in Spring House, PA, to drive early- to clinical-stage bioprocess development for biologics and gene therapies. You will design and execute studies, optimize media and scale-up processes, and collaborate across disciplines to enable robust manufacturing strategies.

The role requires hands-on bioreactor experience, data-driven decision making, and strong communication.

Qualifications

• BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field with 2-4+ years of relevant experience.
• Experience in mammalian cell culture process development for biologics, cell and gene therapy, RNA therapeutics, or related viral vector modalities.
• Hands-on experience with bioreactor operation, media optimization, process monitoring, and process scale-up support.
• Experience with Ambr® 250 high-throughput bioreactor systems.
• Strong data analysis, experimental design, and technical documentation skills.
• Excellent written and verbal communication skills and ability to work effectively in cross-functional teams.

Responsibilities

• Design and execute upstream process development studies for lentiviral in vivo therapeutic products under scientific guidance.
• Perform cell culture experiments using shake flasks, bench-scale bioreactors, and automated high-throughput systems.
• Support development of scalable fed-batch and perfusion processes to improve productivity, quality, and manufacturability.
• Utilize Ambr® 250 bioreactor systems for process development, media optimization, and scale-down model studies.
• Apply statistical experimental design, data analytics, and visualization tools to support process understanding and decision-making.
• Build working knowledge of Process Analytical Technology, Raman spectroscopy, online monitoring, and digital bioprocessing tools.
• Analyze and interpret process data using JMP, MiniTab, Python, Spotfire, or similar platforms.
• Support evaluation of novel upstream technologies that improve process robustness and development efficiency.
• Collaborate with downstream, analytical, automation, modeling, and formulation teams to align study design and deliverables.
• Author technical reports, development summaries, protocols, and regulatory-supporting documentation.

Skills

Upstream process development

Mammalian cell culture

Data analysis

Experiment design

Communication

Education

BS/MS in Chemical/Biochemical Engineering or related field

Tools

Ambr 250

Job description

Johnson & Johnson is seeking a Scientist, Upstream Process Development in Spring House, PA, to drive early- to clinical-stage bioprocess development for biologics and gene therapies. You will design and execute studies, optimize media and scale-up processes, and collaborate across disciplines to enable robust manufacturing strategies.

The role requires hands-on bioreactor experience, data-driven decision making, and strong communication.