Scientist – Lentiviral Vector Downstream Process Development

6084-Janssen Research & Development, LLC Legal Entity; Spring House (PA); On-site; USD 110,000 - 140,000; Full time

Job summary

Johnson & Johnson in Spring House, PA, seeks a Scientist – Lentiviral Vector Downstream Process Development to lead purification process development for cell therapy programs, focusing on scalable downstream purification, data-driven process understanding, and technology transfer to GMP manufacturing sites.

Responsibilities include designing studies, performing chromatography and filtration experiments, optimizing processes, and collaborating with upstream, analytical, and formulation teams to

Qualifications

• BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field with 2-4 years of industry experience; or viral product process development experience.
• Experience with purification of biologics, cell/gene therapy, RNA therapeutics, or viral vector modalities.
• Hands-on chromatography, clarification, depth filtration, UF/DF, sterile filtration, and scale-up.
• Strong data analysis, experimental design, and technical documentation skills.
• Excellent written and verbal communication; cross-functional teamwork; prefer tech transfer experience to GMP manufacturing.
• Occasional weekend work; up to 10% travel.

Responsibilities

• Design and execute downstream studies for lentiviral products under guidance.
• Perform chromatography, filtration, UF/DF, and formulation experiments; use automated high-throughput systems.

Skills

Analytical reasoning

Biochemistry

Chemistry

Manufacturing

CMC

Coaching

Collaboration

Conducting experiments

Data quality

Drug discovery development

Molecular diagnostics

Patent applications

Pharmacogenetics

Report writing

Research documents

Scientific research

Technologically savvy

Written expression

Education

BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field

Tools

AKTA systems

TFF systems

JMP

MiniTab

Python

Spotfire

Job description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Biotherapeutics R&D

Job Category

Scientific/Technology

All Job Posting Locations

Spring House, Pennsylvania, United States of America

We are searching for the best talent for a Scientist – Lentiviral Vector Downstream Process Development to be based in Spring House, PA.

Purpose

The Scientist, Lentiviral Vector Downstream Process Development, will lead development, optimization, and characterization of scalable purification processes for cell therapy and CAR-T programs. This role will contribute to early- or clinical-stage process development, with emphasis on purification process strategy at varying scales and data-driven process understanding, platform knowledge and robustness, and optimization of downstream process technologies. This role will also support technology transfer to Johnson & Johnson’s manufacturing sites, commercial manufacturing investigations and provide subject matter expert knowledge as part of life cycle management for cell therapy products in Johnson & Johnson’s pipeline.

You will be responsible for

• Design and execute downstream process development studies for lentiviral therapeutic products under scientific guidance
• Conduct purification experiments including chromatography, filtration, UF/DF, and formulation, and automated high-throughput systems
• Contribute to development of lentiviral processes to continuously improve productivity, quality, and manufacturability.
• Oversee operation and management of downstream equipment, including AKTA systems, TFF systems, and purification skids.
• Perform technology transfer to and collaborate with Johnson & Jonnson’s manufacturing sites
• Support existing and new commercial manufacturing investigations and provide subject matter expert knowledge as part of product life cycle management
• Apply statistical experimental design, data analytics, and online monitoring and visualization tools to strengthen downstream process understanding.
• Analyze and interpret process data using JMP, MiniTab, Python, Spotfire, or similar platforms.
• Evaluate emerging novel downstream technologies that improve process robustness and development efficiency.
• Collaborate closely with upstream, analytical, formulation, modeling, automation to align study design and deliverables
• Author technical reports, development summaries, scientific presentations, protocols, and regulatory-supporting documentation.

Qualifications

• BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field with 2-4 years of relevant industry experience; OR Experience with process development of viral based products. Experience in purification process development for biologics, cell and gene therapy, RNA therapeutics, or related viral vector modalities. Hands‑on experience with chromatography, clarification, depth filtration, UF/DF, sterile filtration, and process scale‑up. Strong data analysis, experimental design, and technical documentation skills. Excellent written and verbal communication skills. Ability to work effectively in cross‑functional team environments. Previous experience with technology transfer of a bioprocess to clinical or commercial GMP manufacturing is strongly preferred.
• Occasional weekend work may be required
• Up to 10% domestic and international travel may be required

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center ([e-mail]) or contact AskGS to be directed to your accommodation resource.

Required Skills

Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Collaboration, Conducting Experiments, Data Quality, Drug Discovery Development, Molecular Diagnostics, Patent Applications, Pharmacogenetics, Report Writing, Research Documents, Scientific Research, Technologically Savvy, Written Expression

Preferred Skills

Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Collaboration, Conducting Experiments, Data Quality, Drug Discovery Development, Molecular Diagnostics, Patent Applications, Pharmacogenetics, Report Writing, Research Documents, Scientific Research, Technologically Savvy, Written Expression

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

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