Senior Scientist I, Lentiviral Engineering & In Vitro Assay Development
AbbVie
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Job summary
AbbVie seeks a Senior Scientist to join Genetic Medicine in vivo CAR-T. You will design and execute experiments to advance lentiviral-based delivery platforms, engineer vectors, and collaborate across teams to push the CAR-T program from discovery through translational development.
You will mentor junior scientists, author publications and assist in patent work, while maintaining rigorous ELN records and ensuring safety in a BSL-2 environment.
Qualifications
- Expertise in mammalian primary cell and cell line culture, including T cells and PBMCs.
- Experience with multi-color flow cytometry and immunoassays such as ELISA or Luminex.
- Proven ability to develop and troubleshoot high-throughput assays.
- Experience with lentiviral vector design, production, and analysis is highly preferred.
- Strong communication, collaboration, and scientific documentation skills.
Responsibilities
- Lead research efforts and design in vitro studies to advance lentiviral delivery platforms.
- Engineer lentiviral vectors and fusion receptors; oversee production via internal/external partners.
- Collaborate with cross-functional teams to advance CAR-T pipeline from discovery to translational development.
- Maintain thorough ELN records and interpret multidisciplinary data to guide experiments.
- Contribute as a primary author to publications and patent applications; mentor junior scientists.
Skills
Education
Tools
Job description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
AbbVie is looking for a Senior Scientist to join our Genetic Medicine in vivo CAR-T group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to in vivo lentiviral delivery platforms. The successful candidate will drive scientific innovation, identify and implement new methods and techniques, and collaborate cross-functionally to advance our pipeline of novel in vivo CAR-T therapies.
- Lead research efforts, design and execute in vitro studies (multi-color flow cytometry, ELISA, luciferase, ddPCR, etc.) and collaborate with in vivo pharmacology group for in vivo studies to advance lentiviral-based delivery platform development.
- Design and engineer lentiviral vectors and fusion protein receptors, and oversee lentiviral production by leveraging internal capabilities and external CRO partnerships.
- Partner with cross-functional and therapeutic area teams to advance lentiviral-based in vivo CAR-T pipeline programs from early discovery through translational development.
- Uphold company culture, teamwork, and safety standards, including appropriate handling of materials in a BSL-2 environment.
- Work independently with minimal supervision while maintaining a high level of productivity, efficiency, and scientific rigor.
- Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).
- Analyze and interpret multidisciplinary data to generate actionable conclusions, identify key risks, and guide future experimental directions.
- Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
- Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
- Demonstrate a proactive, solutions-oriented mindset and take ownership of additional responsibilities as needed.
- Mentor and support junior scientists within the team.
- BS, MS, or PhD in immunology, oncology, cell biology, molecular biology, biochemistry, or related field with typically 10+ (BS), 8+ (MS), or 0-3+ (PhD) years of experience.
- Expertise in mammalian primary cell and cell line culture (primary T cells, PBMCs, whole blood, suspension and adherent cell lines), multi-color flow cytometry (panel design, acquisition, and analysis), and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.
- Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is highly preferred.
- Experience with lentiviral vector design, production, and analytical characterization (e.g., titering, copy number analysis, transduction efficiency assessment) is highly preferred.
- Experience in evaluating vector biodistribution, transduction specificity, or safety-related parameters is a plus.
- Experience in CAR-T cell therapy and/or in vivo targeted delivery is a plus.
- Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
- Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
- Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.
- Detail-oriented with a passion for delivering high-quality results.
AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
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