Senior Scientist I, Lentiviral Engineering & In Vitro Assay Development

AbbVie Inc.; South San Francisco (CA); On-site; USD 97,000 - 184,000; Full time

Job summary

AbbVie Inc. is seeking a Senior Scientist to join the Genetic Medicine in vivo CAR-T group within Biotherapeutics and Genetic Medicine.

You will design and execute innovative experiments to address challenges in in vivo lentiviral delivery platforms and drive new methods for CAR-T therapies. You will lead cross-functional collaboration, mentor junior scientists, and contribute to publications, while maintaining rigorous scientific standards in a fast-paced environment at AbbVie’s South San

Qualifications

• PhD/MS/BS in immunology or related field with experience levels as noted in the job description.
• Expertise in mammalian primary cell culture and multi-color flow cytometry required.
• Experience in cell-based in vitro assay development and semi-automated liquid handling is highly preferred.
• Experience with lentiviral vector design, production, and analytical characterization is highly preferred.

Responsibilities

• Lead in vivo and in vitro studies using multi-color flow cytometry and ELISA.
• Design and engineer lentiviral vectors and receptors; oversee production and collaborations with CROs.
• Advance lentiviral-based in vivo CAR-T pipeline from discovery to translational development.
• Maintain ELN records and ensure safety in a BSL-2 environment.
• Collaborate with cross-functional teams and contribute to publications and patents.

Skills

Immunology

Mammalian cell culture

Flow cytometry

ELISA

Lentiviral vectors

Education

PhD in immunology/oncology/cell biology

MS in relevant field

BS in relevant field

Tools

Lentiviral vector production

Job description

• Full-time
• Salary Min: 96500
• Salary Max: 183500
• Workday Global Grade: 17
• Compensation: USD 96,500 - USD 183,500 - yearly

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

Job Description

AbbVie is looking for a Senior Scientist to join our Genetic Medicine in vivo CAR-T group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to in vivo lentiviral delivery platforms. The successful candidate will drive scientific innovation, identify and implement new methods and techniques, and collaborate cross-functionally to advance our pipeline of novel in vivo CAR-T therapies.

Responsibilities:

• Lead research efforts, design and executein vitrostudies (multi-color flow cytometry, ELISA, luciferase, ddPCR, etc.) and collaborate with in vivo pharmacology group forin vivostudies to advance lentiviral-based delivery platform development.
• Design and engineer lentiviral vectors and fusion protein receptors, and oversee lentiviral production by leveraging internal capabilities and external CRO partnerships.
• Partner with cross-functional and therapeutic area teams to advance lentiviral-based in vivo CAR-T pipeline programs from early discovery through translational development.
• Uphold company culture, teamwork, and safety standards, including appropriate handling of materials in a BSL-2 environment.
• Work independently with minimal supervision while maintaining a high level of productivity, efficiency, and scientific rigor.
• Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).
• Analyze and interpret multidisciplinary data to generate actionable conclusions, identify key risks, and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Demonstrate a proactive, solutions-oriented mindset and take ownership of additional responsibilities as needed.
• Mentor and support junior scientists within the team.

Qualifications

• BS, MS, or PhD inimmunology, oncology, cell biology, molecular biology, biochemistry, or related field with typically 10+ (BS), 8+ (MS), or 0-3+ (PhD)years of experience.
• Expertise in mammalian primary cell and cell line culture (primary T cells, PBMCs, whole blood, suspension and adherent cell lines), multi-color flow cytometry (panel design, acquisition, and analysis), and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.
• Experience in cell-basedin vitroassay development and semi-automated liquid handling systems for high-throughput workflows is highly preferred.
• Experience with lentiviral vector design, production, and analytical characterization (e.g., titering, copy number analysis, transduction efficiency assessment) is highly preferred.
• Experience in evaluating vector biodistribution, transduction specificity, or safety-related parameters is a plus.
• Experience in CAR-T cell therapy and/orin vivotargeted delivery is a plus.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.
• Detail-oriented with a passion for delivering high-quality results.

Why AbbVie?
AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: