Lead Systems Engineer

MantaBio, Inc.; Beverly, Northern (MA, KY); Hybrid; USD 150,000 - 190,000; Full time

Benefits offered by this job

Equity ownership

Medical benefits

Unlimited PTO

Exposure to cutting-edge science

Access to leadership

Job summary

MantaBio, Inc. is seeking a Lead Systems Engineer in Beverly, MA to integrate mechanical, electrical, fluidic, optical, and consumable components into a cohesive platform.

You will drive the development from prototype to commercial readiness with a hands-on, autonomous startup mindset. The role requires deep technical fluency, cross-disciplinary collaboration, and the ability to work across software, biology, chemistry, and electronics teams.

Qualifications

• 10+ years of hardware-focused systems engineering experience.
• MS in Engineering preferred.
• CAD experience, SolidWorks strongly preferred.

Responsibilities

• Design and build electromechanical subsystems including fluid handling, thermal cycling, and optical detection.
• Develop breadboards and alpha prototypes to mitigate technical risk prior to commercial development.
• Integrate pumps, valves, manifolds, heaters, sensors, and optics into reliable systems.

Skills

Systems engineering

Hardware integration

CAD - SolidWorks

Python

MATLAB

Hands-on

10+ years exp

Education

MS in Engineering

Tools

SolidWorks

Job description

Building the technology biopharma actually needs.

At MantaBio, we're building technology that helps biopharma manufacturers detect microbial contamination in real time — dramatically reducing risk and accelerating timelines for the therapies that depend on it.

Our mission is to replace outdated, slow cell-culture testing with fast, accurate, and automated solutions that meet the needs of modern biologics production. Everyone here plays a hands-on role in shaping the product, the company, and the culture.

If you're energized by building from the ground up — and want your work to matter — we'd love to meet you.

Why work with us.

We're not just building a product — we're solving a real problem in an industry that needs better tools. Your work has clear purpose and immediate impact.

• Meaningful equity ownership — be part of the upside
• Full medical, dental, and vision benefits
• Unlimited PTO — we trust you to take the time you need
• Exposure to cutting-edge science and automation
• Direct access to leadership and rapid career growth

Beverly, MA

About the Role

As Lead Systems Engineer, you'll be instrumental in integrating mechanical, electrical, fluidic, optical, and consumable components into a cohesive platform. You'll help drive development of a complex, fully integrated product — transitioning from prototype to commercial readiness. This role requires deep technical fluency, cross-disciplinary thinking, and a hands‑on approach.

What You'll Do — Systems Integration & Prototyping

• Design and build electromechanical subsystems including fluid handling, thermal cycling, and optical detection.
• Develop breadboards and alpha prototypes to mitigate technical risk prior to commercial development.
• Integrate pumps, valves, manifolds, heaters, sensors, and optics into reliable systems.

Design & Development

• Use CAD (SolidWorks preferred) for mechanical design and support prototyping via CNC machining, 3D printing, or injection molding.
• Analyze experimental data to inform iterative design (bonus points for Python or MATLAB fluency).

Cross-Functional Collaboration

• Partner with software, biology, chemistry, and electronics teams to ensure seamless integration.
• Operate with autonomy and a "get it done fast" mindset in a startup environment.

What You Bring

• 10+ years of experience as a systems engineer in hardware-focused environments.
• MS in Engineering preferred but not required.
• Proficiency in CAD and one or more data analysis environments (Python, MATLAB, etc.).
• Hands‑on, self‑directed, and execution‑driven mindset.

What We Offer

• Salary: Competitive within early‑stage startups
• Benefits: Health, dental, vision, and 401(k)