Principal Mechanical Engineer

Cellino; Cambridge (MA); On-site; USD 150,000 - 190,000; Full time

Benefits offered by this job

Stock options

401(k)

Employer‑paid medical, dental, vision,

Life insurance

FSA/HSA available

Generous PTO & holidays

Parental leave

Job summary

Cellino Biotech, Inc. is seeking a hands‑on principal mechanical engineer to turn research concepts into production‑ready designs.

You will own mechanical development from concept to production, work with R&D, vendors, and global suppliers, and mentor junior engineers to deliver high‑quality fluidic and mechatronic systems. The ideal candidate has 10+ years of mechanical design experience, proficiency in CAD, and a track record of shipping complex products from prototype to production.

Qualifications

• 10+ years in mechanical design and product development.
• Proven ownership of a complex mechanical product from concept to production.
• Expert in 3D CAD; proficient with prototyping and manufacturing processes.

Responsibilities

• Own mechanical development from concept through prototyping, verification, design transfer, and production.
• Drive projects independently, identify risks, resolve ambiguity, escalate when needed.
• Coordinate across internal teams, vendors, CMOs, and global suppliers; mentor juniors.
• Collaborate with R&D and biologists on fluidic and mechatronic system concepts.
• Apply DFM principles to ensure quality and production efficiency.

Skills

Leadership on complex projects

3D CAD (SolidWorks/AutoCAD)

Prototyping (3D printing, CNC)

DFM/DFA, GD&T, tolerancing

Mechanical design & product dev

Education

Bachelor's in Mechanical Engineering

Tools

SolidWorks

AutoCAD

Job description

Cellino Biotech, Inc. is an innovation- and value-driven, venture capital-backed biotechnology company that is pioneering a transformative platform to manufacture cell-based therapies. The company was founded by a team of interdisciplinary, entrepreneurial scientists and engineers with expertise in laser physics, biology, software development, optics, precision instrumentation, and business.

We are seeking a hands‑on principal mechanical engineer to work with our R&D team to turn research concepts into functional designs, then shepherd them through prototyping into production. Key areas include laboratory consumables, liquid handling systems, and mechatronics. The ideal candidate has been the technical leader on complex projects, mentored team members and established the approach to mechanical engineering at a past company.

Candidates should supply a portfolio and be ready to present a shipping product where they were the primary technical contributor from prototype to production.

Responsibilities

• Own the mechanical development of products and subsystems from concept through prototyping, verification, design transfer, and production.
• Drive projects forward independently, identifying technical risks, resolving ambiguity, and escalating issues when appropriate.
• Coordinate mechanical development across internal teams, vendors, contract manufacturers, and global suppliers, and provide technical direction to junior engineers, technicians, consultants, and external development partners.
• Collaborate closely with R&D engineers and cell biologists to understand new product concepts, requirements, and designs for fluidic and mechatronic systems
• Implement design for manufacturing (DFM) principles to ensure quality and efficiency in production

Requirements

• 10+ years of experience in mechanical design and product development, with a Bachelor's degree in Mechanical Engineering or a related field.
• Demonstrated experience independently owning a complex mechanical product or subsystem from initial concept through production.
• Expert proficiency in 3D CAD software like SolidWorks, AutoCAD, etc.
• Extensive hands‑on experience with prototyping methods (3D printing, CNC, fabrication)
• Strong knowledge of manufacturing processes (injection molding, casting, machining), design for manufacturing and assembly (DFM/DFA) principles, detailed tolerance analysis, and GD&T.

Nice‑to‑Have Skills and Background

• Understanding of fluid dynamics, motion control, and mechatronics
• Experience with microcontrollers, firmware, automation, and Python
• Experience with high-volume medical or biological plastics manufacturing
• Simulation and analysis experience (FEM, Comsol, Ansys)
• Stock options
• 401(k)
• Employer‑paid medical, dental, vision, and life insurance
• Flexible Spending Account (FSA) and Health Savings Account (HSA) available
• Generous paid time off and sick leave + 12 company holidays
• Parental leave
• It is the policy of Cellino Biotech, Inc. to provide equal employment opportunity for all applicants and employees. The Company does not unlawfully discriminate on the basis of race, religion, creed, color, national origin, ancestry, physical and/or mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, transgender status, pregnancy, marital status, age, sexual orientation, and military or veteran status, or any other basis protected by law. It also prohibits unlawful discrimination and harassment based on the perception that anyone has any of those characteristics, or is associated with a person who has or is perceived as having any of those characteristics.

Cellino does not accept unsolicited resumes from any source other than directly from potential candidates. Any resumes submitted by a staffing agency in the absence of a current executed contract will automatically become Cellino's property and no recruiting fees or other obligations will be owed in the event of a potential hiring.