Lead Scientist, Small-Molecule Drug Formulation

C4 Therapeutics, Inc.; Watertown (MA); On-site; USD 230,000 - 254,000; Full time

Job summary

C4 Therapeutics, Inc. is seeking an experienced Small Molecule Drug Product Formulation specialist to lead the design, early-phase development, and manufacturing scale-up of our oral solid dose drug product candidates.

In this role, you will drive progression from initial pre-formulation through technology transfer into GMP manufacturing for clinical trials, serving as the technical lead overseeing external CDMOs.

Qualifications

• PhD with 8+ years in formulation science and manufacturing of solid oral and parenteral dosage forms.
• Experience in cross-functional drug product leadership with interactions with stakeholders.
• Familiarity with cGMPs and Regulatory Guidance Documents for pharmaceutics.
• Experience creating RFPs and managing CDMOs for formulation development.
• Ability to multi-task, present data clearly, and drive development progress with urgency.

Responsibilities

• Lead phase-appropriate small molecule drug product formulation development for clinical portfolio.
• Oversee formulation development, process optimization, scale-up, and tech transfer with external CDMOs.
• Direct and evaluate external scientists and vendors, including CDMO selection and data review.
• Provide technical leadership for batches and review documents to ensure GMP alignment.
• Support CMC strategy and regulatory readiness with memos, specifications, and filings.
• Serve as drug product technical representative across internal and external partners.

Skills

Cross-functional leadership

Data interpretation

Regulatory communication

Education

PhD in Pharmaceutical Chemistry or related field

Job description

C4 Therapeutics, Inc. is seeking an experienced Small Molecule Drug Product Formulation specialist to lead the design, early-phase development, and manufacturing scale-up of our oral solid dose drug product candidates.

In this role, you will drive progression from initial pre-formulation through technology transfer into GMP manufacturing for clinical trials, serving as the technical lead overseeing external CDMOs.