Lead Scientist, mRNA LNP Formulation & Process

Sanofi; Waltham (MA); On-site; USD 110,000 - 190,000; Full time

Job summary

Sanofi in Waltham, MA seeks a Scientist/Engineer to advance mRNA LNP formulation and production, contributing to innovative vaccines with strong formulation and process development skills.

You will design experiments, collaborate with Research to transfer formulations into CMC development, and help establish analytical methods while supporting lab expansion in a fast-paced biopharma setting.

Qualifications

• Bachelor's in Engineering, Pharmaceutical Sciences, or Chemistry-related field with 5+ years of professional formulation and/or process development experience.
• Master's in Engineering, Pharmaceutical Sciences, or Chemistry-related field with 3+ years of experience in formulation and/or process development; internships/co-ops considered.
• Ph.D. in Engineering, Pharmaceutical Sciences, or Chemistry-related field with at least 6 months of experience in formulation and/or process development; academic experience considered.

Responsibilities

• Lead the formulation optimization and/or process understanding of mRNA-containing LNP formulation and production processes.
• Collaborate with Research to transfer and accelerate new LNP formulations into CMC development.
• Design and conduct small-scale multi-component LNP formulation experiments to understand developability.
• Lead compilation of Developability package for new LNP formulations.
• Develop initial formulation process for new LNP formulations.
• Plan studies to assess stability of new LNP formulations.
• Perform in-process drug product characterization and analytical methods.
• Coordinate advanced LNP characterization analyses with Analytics.

Skills

LNP formulation

Formulation development

Process development

Analytical characterization

Experiment design

Cross-functional collaboration

LNP production processes

Data interpretation

Education

Bachelor's in Engineering/Pharmaceutical Sciences/Chemistry

Master's in Engineering/Pharmaceutical Sciences/Chemistry

PhD in Engineering/Pharmaceutical Sciences/Chemistry

Tools

Electronic Lab Notebook (ELN)

Lipid nanoparticle characterization techniques

Job description

Sanofi in Waltham, MA seeks a Scientist/Engineer to advance mRNA LNP formulation and production, contributing to innovative vaccines with strong formulation and process development skills.

You will design experiments, collaborate with Research to transfer formulations into CMC development, and help establish analytical methods while supporting lab expansion in a fast-paced biopharma setting.