Lead Scientist, mRNA & Enzymatic Synthesis

Hongene Biotech Corporation; Union City (CA); On-site; USD 103,000 - 130,000; Full time

Job summary

Hongene Biotech Corporation in Union City, CA seeks a Senior Scientist – mRNA & Enzymatic Synthesis to lead design and execution of sgRNA, siRNA, and mRNA projects. You will mentor team members and collaborate with synthesis colleagues, using IVT and enzymatic ligation expertise.

Responsibilities include purifying products, analyzing data, troubleshooting workflows, and maintaining rigorous SOPs in a lab setting. On-site role with 103k–130k USD salary.

Qualifications

• Ph.D. in Biochemistry, Molecular Biology, Nucleic Acid Chemistry, or related field required; 0–2 years industry experience or BS/MS with relevant biotech experience.

Responsibilities

• Design, execute, and optimize sgRNA production using enzymatic ligation to support gene-editing programs.
• Synthesize and characterize siRNA constructs using the ligation platform; optimize yield and purity.
• Develop, execute, and troubleshoot IVT processes to produce robust, well-characterized mRNA.
• Purify enzymatic products via preparative HPLC and analyze with HPLC and Fragment Analyzer.
• Troubleshoot ligation, IVT, and purification workflows; drive protocol improvements.
• Mentor Chemists and Scientists in enzymatic synthesis, IVT, and molecular biology.

Job description

Hongene Biotech Corporation in Union City, CA seeks a Senior Scientist – mRNA & Enzymatic Synthesis to lead design and execution of sgRNA, siRNA, and mRNA projects. You will mentor team members and collaborate with synthesis colleagues, using IVT and enzymatic ligation expertise.

Responsibilities include purifying products, analyzing data, troubleshooting workflows, and maintaining rigorous SOPs in a lab setting. On-site role with 103k–130k USD salary.