Lead Scientist, DAC Bioanalysis & LC-MS/MS

BioSpace; Brisbane (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Nurix Therapeutics is seeking a Scientist to lead bioanalytical strategies for next-generation degrader antibody conjugates (DACs). You will focus on LC-MS/MS and hybrid assays to quantify conjugates and metabolites across discovery and early development, coordinating cross-functional teams.

The role requires Ph.D. or MS with extensive relevant experience, expert LC-MS/MS capabilities, and a collaborative, fast-paced mindset to drive data-driven decisions in preclinical studies.

Qualifications

• Ph.D. with 5+ years or M.S. with 8+ years in Bioanalysis or Analytical Chemistry.
• Deep expertise in LC-MS/MS bioanalysis, including method development, qualification/validation.
• Experience with Sciex platforms and high-resolution MS.
• Strong background in ADCs, DACs, or related bioconjugates.
• Experience supporting in vitro ADME and in vivo PK studies.
• Proficiency in sample preparation for large molecules and bioconjugates.
• Strong data analysis, visualization, and reporting skills.
• Excellent written and verbal communication skills.
• Ability to work in a fast-paced, collaborative environment.

Responsibilities

• Lead the development, qualification, and execution of bioanalytical methods for DAC modalities.
• Design LC-MS/MS workflows for quantitative payload analysis on small molecules.
• Apply high-resolution MS platforms for DAC characterization and metabolite ID.
• Develop hybrid LBA–LC-MS/MS strategies for conjugate quantitation.
• Plan and interpret in vitro studies including stability and kinetics.
• Lead bioanalytical support for in vivo PK and tissue distribution studies.
• Characterize biotransformation pathways of DACs and payload metabolites.
• Collaborate with DMPK, Proteomics, Pharmacology, and Chemistry teams.
• Author technical reports and regulatory documentation with rigor.
• Troubleshoot matrix effects and conjugate heterogeneity.
• Mentor junior scientists and help build bioanalytical capabilities.
• Evaluate new technologies to advance protein degrader modalities.
• Identify and oversee CROs for method development and transfer.

Skills

LC-MS/MS bioanalysis

High-resolution MS

Data analysis & visualization

Scientific writing & reporting

Team collaboration

Mentoring

Regulatory knowledge

Education

Ph.D. in Bioanalysis / Analytical Chemistry or related field

M.S. in Bioanalysis / Analytical Chemistry or related field

Tools

Sciex platforms (7600 ZenoTOF, 6500+, 7500)

High-resolution MS instruments

Job description

Nurix Therapeutics is seeking a Scientist to lead bioanalytical strategies for next-generation degrader antibody conjugates (DACs). You will focus on LC-MS/MS and hybrid assays to quantify conjugates and metabolites across discovery and early development, coordinating cross-functional teams.

The role requires Ph.D. or MS with extensive relevant experience, expert LC-MS/MS capabilities, and a collaborative, fast-paced mindset to drive data-driven decisions in preclinical studies.