Lead Scientist, Cellular Neuroscience & Translation

Lexeo Therapeutics, Inc.; New York (NY); On-site; USD 110,000 - 160,000; Full time

Job summary

Lexeo Therapeutics, Inc. seeks a highly collaborative Scientist II to establish a preclinical neuroscience lab supporting small‑molecule and transferrin‑based protein replacement programs.

Lead rapid cellular profiling, develop human neuronal models, build workflows, and drive lead selection while partnering with multiple disciplines and CROs. The role emphasizes hands‑on laboratory leadership, data‑driven decision making, and mentoring junior scientists, with opportunities to shape future ASO

Qualifications

• PhD in pharmacology, neuroscience, molecular biology, chemical biology, cell biology, or related discipline.
• 1–3 years biotechnology or pharmaceutical industry experience.
• Experience in cellular pharmacology, assay development, and lead optimization.

Responsibilities

• Lead rapid, tiered cellular assay strategy for small‑molecule lead optimization.
• Lead cellular development of a transferrin‑based protein replacement project with quantitative assays.
• Use orthogonal methods to distinguish surface-bound vs internalized protein and compare constructs.
• Establish fit‑for‑purpose neuronal culture models (iPSC-derived neurons/glia) with proper QC.
• Define assay controls, acceptance criteria, reproducibility standards, SOPs, sample tracking and documentation.
• Translate data into concise recommendations to advance or discontinue assets.
• Partner across protein engineering, chemistry, bioanalysis, DMPK, pathology, computational biology; manage CROs.
• Mentor junior scientists and build reproducible workflows; future ASO screening possible.

Skills

Cellular pharmacology

Assay development

Drug discovery

Lead optimization

Neuronal culture

iPSC neurons

Data analysis

Troubleshooting

Scientific ownership

Communication skills

Education

PhD in relevant field

Job description

Lexeo Therapeutics, Inc. seeks a highly collaborative Scientist II to establish a preclinical neuroscience lab supporting small‑molecule and transferrin‑based protein replacement programs.

Lead rapid cellular profiling, develop human neuronal models, build workflows, and drive lead selection while partnering with multiple disciplines and CROs. The role emphasizes hands‑on laboratory leadership, data‑driven decision making, and mentoring junior scientists, with opportunities to shape future ASO