Neuro Translational Scientist: Cellular Pharmacology Lead

Lexeo Therapeutics; New York (NY); Sur place; USD 127 000 - 150 000; Plein temps

Résumé du poste

Lexeo Therapeutics seeks a Scientist II to establish a preclinical neuroscience laboratory supporting small-molecule and protein therapeutics. Lead rapid cellular profiling for lead optimization and drive cellular development for a transferrin-based protein replacement project, building fit-for-purpose neuronal models and workflows with external partnerships.

The role includes mentoring junior scientists, partnering across R&D teams, and expanding capabilities to ASO screening in the future;

Qualifications

• PhD in pharmacology, neuroscience, molecular biology, chemical biology, cell biology, or a related discipline.
• 1 to 3 years biotechnology/pharmaceutical industry experience.
• Hands-on experience in cellular pharmacology, assay development, and iterative drug discovery/lead optimization.
• Neuronal cell culture model experience, preferably human iPSC-derived neurons or glia.
• Experience with concentration–response, time-course, target engagement, pharmacodynamic, quantitative data analysis, and troubleshooting.

Responsabilités

• Lead a rapid, tiered cellular assay strategy for small-molecule lead optimization, including target engagement, pharmacodynamics, concentration-response, duration, selectivity, neuronal phenotype, stress, and tolerability.
• Lead cellular development of a transferrin-based protein replacement project by establishing quantitative assays for construct uptake, internalization, intracellular trafficking, protein abundance and integrity, mitochondrial response, and disease-relevant phenotypic rescue.
• Use orthogonal methods to distinguish surface-bound, internalized, degraded, and functionally delivered protein; compare constructs and define advancement criteria.
• Establish fit-for-purpose neuronal culture models, including iPSC-derived neurons or glia where they add decision value, with appropriate banking and quality control.
• Define assay controls, acceptance criteria, reproducibility standards, analysis plans, SOPs, sample tracking, and electronic documentation.
• Translate data into concise recommendations to advance, modify, or discontinue assets.
• Partner across protein engineering, chemistry, bioanalysis, DMPK, pathology, computational biology, and in vivo pharmacology; scientifically manage CROs and assay transfers.
• Mentor junior scientists and build workflows that are reproducible across operators. Future scope may include ASO screening in partnership with external experts.

Connaissances

Cellular pharmacology

Assay development

Neuronal cell culture

Data analysis

Scientific ownership

Communication skills

Formation

PhD in relevant field

Outils

CRO management

Description du poste

Lexeo Therapeutics seeks a Scientist II to establish a preclinical neuroscience laboratory supporting small-molecule and protein therapeutics. Lead rapid cellular profiling for lead optimization and drive cellular development for a transferrin-based protein replacement project, building fit-for-purpose neuronal models and workflows with external partnerships.

The role includes mentoring junior scientists, partnering across R&D teams, and expanding capabilities to ASO screening in the future;