Lead Researcher: In Vivo & In Vitro Drug Screening

Thecentermemphis; Memphis (TN); On-site; USD 60,000 - 105,000; Full time

Job summary

St. Jude Children’s Research Hospital seeks a Lead Researcher to investigate therapeutic approaches for pediatric cancers, focusing on leukemia and medulloblastoma.

You will lead drug screening and genomic analyses, defining mechanisms of drug response with molecular and cell-based assays. The role requires hands-on molecular biology experience, including cell culture, flow cytometry, DNA/RNA isolation, and western blotting, plus expertise in drug screening and in vivo studies.

Qualifications

• Bachelor’s degree in a relevant scientific area is required.
• 5+ years of research experience is required.
• 3+ years of experience is required with a Master’s degree.
• No prior experience required with a PhD.
• Strong knowledge and experience in understanding and application of underlying principles related to techniques being performed.
• Experience in R&D methods and processes in lab setting, and execution of research projects for the laboratory preferred.
• Proven performance in earlier role/comparable role.

Responsibilities

• Lead and perform in vitro and in vivo drug screening studies using established primary and patient-derived leukemia and medulloblastoma models.
• Design and execute dose-response, viability, combination, and drug-synergy studies.
• Develop, optimize, and troubleshoot cell-based and molecular assays.
• Utilize short- and long-read RNA-seq and other genomics approaches to investigate mechanisms of therapeutic response.
• Analyze and interpret experimental data, prioritize candidates to advance studies toward in vivo validation.
• Design and/or coordinate in vivo efficacy studies.
• Maintain comprehensive and well-organized experimental records.

Skills

Molecular biology

Cell biology

Cell culture

Flow cytometry

DNA/RNA isolation

Western blotting

Functional assays

Drug screening

Genomics

Cancer models

In vivo studies

Education

Bachelor’s degree in a relevant scientific area

Tools

RNA sequencing

In vivo models

Job description

St. Jude Children’s Research Hospital seeks a Lead Researcher to investigate therapeutic approaches for pediatric cancers, focusing on leukemia and medulloblastoma.

You will lead drug screening and genomic analyses, defining mechanisms of drug response with molecular and cell-based assays. The role requires hands-on molecular biology experience, including cell culture, flow cytometry, DNA/RNA isolation, and western blotting, plus expertise in drug screening and in vivo studies.