Lead Researcher - In Vivo & In Vitro Cancer Screening

CHEManager International; Memphis (TN); On-site; USD 60,000 - 105,000; Full time

Job summary

St. Jude Children's Research Hospital seeks a Lead Researcher to investigate therapeutic approaches for pediatric cancers, focusing on leukemia and medulloblastoma.

You will lead and support in vitro and in vivo drug screening, study dose-response, combinations, and mechanisms of drug response using genomics and molecular biology. Ideal candidates have hands-on experience in cell culture, flow cytometry, RNA/DNA isolation, western blotting, and functional assays, with a track record in cancer

Qualifications

• Bachelor's degree in a relevant scientific area is required.
• 5+ years of research experience is required.
• 3+ years of experience with a Master's degree required.
• No prior experience required with a PhD.
• Strong knowledge and experience in underlying principles related to techniques performed.
• Experience in R&D methods and processes in lab setting, and execution of research projects.

Responsibilities

• Lead and perform in vitro and in vivo drug screening studies using established primary and patient-derived leukemia and medulloblastoma models
• Design and execute dose-response, viability, combination, and drug-synergy studies
• Develop, optimize, and troubleshoot cell-based and molecular assays
• Utilize short- and long-read RNA-seq and other genomics approaches to investigate mechanisms of therapeutic response
• Analyze and interpret experimental data, prioritize candidates to advance studies toward in vivo validation
• Design and/or coordinate in vivo efficacy studies
• Maintain comprehensive and well-organized experimental records

Education

Bachelor's degree in a relevant scientific area

Job description

St. Jude Children's Research Hospital seeks a Lead Researcher to investigate therapeutic approaches for pediatric cancers, focusing on leukemia and medulloblastoma.

You will lead and support in vitro and in vivo drug screening, study dose-response, combinations, and mechanisms of drug response using genomics and molecular biology. Ideal candidates have hands-on experience in cell culture, flow cytometry, RNA/DNA isolation, western blotting, and functional assays, with a track record in cancer