Senior Radiochemist

American Radiolabeled Chemicals; St. Louis (MO); On-site; USD 90,000 - 130,000; Full time

Job summary

American Radiolabeled Chemicals, Inc. seeks a skilled radiochemistry chemist to design and execute multi-step syntheses of Carbon-14 and Tritium labeled compounds.

You will develop routes for custom projects, purify intermediates and products, and verify identity with HPLC, MS, NMR, and IR. Responsibilities include troubleshooting challenging purification steps, maintaining detailed notebooks, and producing technical summaries.

Qualifications

• Significant hands-on experience in multi-step organic synthesis, preferably involving Carbon-14 and Tritium labeled compounds.
• Independently execute multi-step synthetic chemistry.
• Strong purification and isolation skills, including HPLC, flash chromatography, SPE, crystallization, and LLE.
• Experience purifying intermediates and final compounds with analytical confirmation.
• Excellent lab documentation and organizational skills.
• Strong troubleshooting and problem-solving abilities.
• Ability to work independently and collaboratively.

Responsibilities

• Design and execute multi-step organic syntheses of Carbon-14 and Tritium labeled compounds.
• Develop and optimize synthetic routes for custom client projects.
• Purify and isolate intermediates and final radiolabeled compounds using HPLC, flash chromatography, SPE, crystallization, and LLE.
• Identify and characterize synthesized compounds using HPLC, MS, NMR, and IR; assess quality.
• Troubleshoot difficult synthetic and purification challenges.
• Maintain laboratory notebooks, experimental records, and project documentation.
• Prepare technical summaries and supporting documentation.
• Ensure safety when handling radioactive materials and collaborate with team.

Skills

Multi-step synthesis

Radiochemistry

Project management

Troubleshooting

Analytical skills

Documentation

Team collaboration

Isotopic labeling

Education

B.S./M.S./Ph.D. in Chemistry

Tools

HPLC

Flash chromatography

Solid-phase extraction

Crystallization

Liquid-liquid extraction

MS

NMR

IR

Job description

• Design and execute multi-step organic syntheses of Carbon-14 and Tritium labeled compounds
• Develop and optimize synthetic routes for custom client projects
• Purify and isolate synthetic intermediates and final radiolabeled compounds using HPLC, flash chromatography, solid-phase extraction, crystallization, and liquid-liquid extraction
• Identify and characterize synthesized compounds using HPLC, mass spectrometry (MS), nuclear magnetic resonance (NMR), and infrared spectroscopy (IR); assess chemical and radiochemical quality
• Troubleshoot difficult synthetic and purification challenges
• Maintain accurate laboratory notebooks, experimental records, and project documentation
• Prepare technical summaries and supporting documentation
• Work safely and effectively with radioactive materials in accordance with established procedures
• Collaborate with chemists, quality personnel, and management
• Manage multiple custom synthesis projects while maintaining quality and project timelines
• Contribute scientific expertise to the continued development of ARC's radiochemistry capabilities

• B.S., M.S., or Ph.D. in Chemistry, Organic Chemistry, Radiochemistry, or a closely related discipline
• Significant hands-on experience in multi-step organic synthesis, preferably involving Carbon-14 and Tritium labeled compounds
• Demonstrated ability to independently execute multi-step synthetic chemistry
• Strong practical knowledge of purification and isolation methods, including HPLC, flash chromatography, solid-phase extraction, crystallization, and liquid-liquid extraction
• Experience purifying both reaction intermediates and final compounds, and confirming compound identity through complementary analytical methods
• Excellent laboratory documentation and organizational skills
• Strong troubleshooting and problem-solving abilities
• Ability to work both independently and collaboratively

PREFERRED QUALIFICATIONS

• Direct experience with Carbon-14 and/or Tritium radiochemistry and multi-step labeled-compound synthesis
• Experience preparing isotopically labeled compounds
• Experience with custom synthesis or contract research projects
• Hands-on experience with HPLC, flash chromatography, solid-phase extraction, and analytical characterization by MS, NMR, and IR; radio-HPLC and radio-TLC are additional advantages
• Experience working under established radiation-safety procedures
• Experience developing synthetic routes from literature research through final compound delivery