Lead PK/PD & Pharmacometrics Modeling Scientist

Jobtailor; Indianapolis (IN); On-site; USD 140,000 - 180,000; Full time

Job summary

Jobtailor is seeking a highly experienced Pharmacometrician to lead population PK/PK‑PD modeling efforts. The role involves independent model development, end‑to‑end analysis, and regulatory submissions, with strong collaboration across statistics, regulatory, medical, and clinical development teams.

The successful candidate will work with NONMEM/Monolix, R, and mrgsolve to deliver robust analyses, communicate complex results, and advance development strategies within a fast‑paced environment.

Qualifications

• PhD in pharmacometrics or related modelling area.
• Experience in population PK and/or PK/PD modeling.
• Experience with NONMEM or Monolix, R, and mrgsolve.
• Hands-on experience across the full modeling workflow, including data handling, exploratory data analysis, covariate evaluation and modeling, evaluation, simulation, and reporting.
• Experience contributing to a regulatory submission or health authority response.
• Reproducible analysis practice, including Git and literate reporting (Quarto).
• Active engagement with AI and automation in a pharmacometrics context.
• Ability to work with cross-functional colleagues.

Responsibilities

• Independently develop, evaluate, and apply population PK/PK‑PD models using NONMEM/Monolix with R for data handling, diagnostics, and simulation.
• Serve as PMx lead on assigned programs.
• Author analysis plans and modeling reports for regulatory submissions.
• Own analyses end to end and provide dose justification and exposure‑response analyses.
• Respond to health authority questions and support vendor analyses.
• Communicate quantitative results to project teams and senior partners.
• Build cross‑functional networks across statistics, regulatory, medical, and clinical development.

Skills

Population PK/PD modeling

Data handling

Exploratory data analysis

Model evaluation

Simulation

Dose justification

Exposure‑response analysis

Reproducible analysis

Cross-functional collaboration

Communication

Education

PhD in pharmacometrics or related modelling area

Tools

NONMEM

Monolix

R

Mrgsolve

Git

Quarto

Job description

Jobtailor is seeking a highly experienced Pharmacometrician to lead population PK/PK‑PD modeling efforts. The role involves independent model development, end‑to‑end analysis, and regulatory submissions, with strong collaboration across statistics, regulatory, medical, and clinical development teams.

The successful candidate will work with NONMEM/Monolix, R, and mrgsolve to deliver robust analyses, communicate complex results, and advance development strategies within a fast‑paced environment.