Lead LC Method Development Scientist & Project Lead

Biogen; Cambridge (MA); On-site; USD 117,000 - 157,000; Full time

Benefits offered by this job

Medical, Dental, Vision, & Life ins.

Fitness & Wellness program

401(k) program with company match

Tuition reimbursement

Job summary

Biogen in Cambridge, MA, is seeking a Scientist II to join the Analytical Development team as an LC SME and Analytical Project Lead. You will drive LC method development, ensure robust stability-indicating methods for synthetic substances, and guide analytical strategy across development programs from early to late stage.

You will collaborate with CMC, formulation, process development, and quality teams, while mentoring others and supporting programs with oligonucleotides and peptides.

Qualifications

• Ph.D. with 0-3 years of relevant experience in pharmaceutical or biotech settings.
• M.S. with 4+ years of relevant experience in pharmaceutical or biotech settings.
• BS with 6+ years of relevant experience in pharmaceutical or biotech settings.
• Deep expertise in small molecule LC method development, with strong experience in HPLC/UHPLC and familiarity with LC-MS.
• Proven ability to lead analytical activities for drug development programs.
• Strong knowledge of ICH guidelines and experience working within regulated (GMP/GLP) environments.
• Excellent problem-solving, communication, and cross-functional collaboration skills.

Responsibilities

• Serve as the LC subject matter expert, leading method development, optimization, qualification, and troubleshooting (HPLC, UHPLC, LC-MS).
• Develop robust, stability-indicating methods for synthetic drug substances and products.
• Provide technical support to inform analytical strategy for development programs from early to late stage.
• Collaborate cross-functionally with CMC, formulation, process development, and quality teams.
• Provide oversight of analytical activities at CDMOs, including method validation, transfer, and lifecycle management aligned with regulatory expectations.
• Participate in mentoring and knowledge-sharing activities to support analytical capability building within the organization.
• Contribute to programs involving emerging modalities (e.g., oligonucleotides and peptides).

Skills

LC method development

HPLC/UHPLC

LC-MS

lead analytical activities

ICH GMP/GLP knowledge

Education

Ph.D.

M.S.

B.S.

Tools

LC-MS

Job description

Biogen in Cambridge, MA, is seeking a Scientist II to join the Analytical Development team as an LC SME and Analytical Project Lead. You will drive LC method development, ensure robust stability-indicating methods for synthetic substances, and guide analytical strategy across development programs from early to late stage.

You will collaborate with CMC, formulation, process development, and quality teams, while mentoring others and supporting programs with oligonucleotides and peptides.