Lead Cytogenetics Technologist — Genomic Stability

Retro Biosciences; Redwood City (CA); On-site; USD 115,000 - 150,000; Full time

Benefits offered by this job

Equity

Health benefits (medical/dental/vision

401(k) match

Unlimited PTO

Learning stipend

Free lunch

Job summary

Retro Biosciences in Redwood City seeks a Cytogenetics Technologist to bring G-banding and karyotyping in-house for the HSC program. You will stand up the workflow, validate performance, and document procedures while maintaining iPSC cultures as needed.

You will perform metaphase arrest, slide preparation, Giemsa staining, imaging, and software‑assisted karyotype analysis, with strong emphasis on accuracy, QC, and clear recordkeeping in a collaborative startup environment.

Qualifications

• Hands-on experience with cytogenetics workflow and karyotype analysis.
• Experience establishing and validating an in-house cytogenetics workflow.
• Strong microscopy and sterile technique in mammalian cell culture.

Responsibilities

• Transfer and implement G-banding and karyotyping workflow in-house for HSC products.
• Execute complete cytogenetics workflow: metaphase arrest, harvest, hypotonic treatment, slide prep, fixation, staining, imaging, analysis.
• Compare in-house results with historical data and document QC criteria.
• Analyze metaphase spreads for numerical/structural abnormalities with clear reporting.
• Support genomic stability assessment of human primary cells.
• Culture, passage, expand, bank, and prepare iPSC samples for karyotyping.
• Track clone-level genomic stability, passages, conditions, and QC across lines.
• Coordinate with CROs for sample shipments and genomic instability analyses.
• Maintain organized records, sample tracking, imaging files, and develop SOPs.

Skills

G-banding

Karyotype analysis

Microscopy

iPSC culture

Imaging software

Education

Bachelor's or Master's in cell biology or related field

CG(ASCP) Cytogenetics certification

Tools

MetaSystems Ikaros

Cytovision

Job description

Retro Biosciences in Redwood City seeks a Cytogenetics Technologist to bring G-banding and karyotyping in-house for the HSC program. You will stand up the workflow, validate performance, and document procedures while maintaining iPSC cultures as needed.

You will perform metaphase arrest, slide preparation, Giemsa staining, imaging, and software‑assisted karyotype analysis, with strong emphasis on accuracy, QC, and clear recordkeeping in a collaborative startup environment.