Lead Computational Protein Engineer: Antibodies & Proteins

Gables Search Group; Rockville (MD); On-site; USD 140,000 - 200,000; Full time

Job summary

Gables Search Group is assisting a research-driven biotechnology organization in Rockville, MD to hire a Computational Protein Engineer who will lead hands-on antibody and protein engineering programs, integrating wet-lab experimentation with computational design to accelerate discovery.

You will apply AlphaFold, Rosetta, and ProteinMPNN, collaborate with structural biologists and chemists, and communicate progress to stakeholders while shaping long-term research impact.

Qualifications

• PhD in biochemistry, molecular biology, protein science, or a related discipline.
• Industry experience conducting hands-on antibody or protein engineering research.
• Strong expertise in protein expression, purification, characterization, and assay development.
• Experience with bispecific antibodies, nanobodies, multispecific proteins, or similar modalities.
• Familiarity with computational protein design and structure-prediction platforms.
• Scientific contributions demonstrated through publications, patents, or successful development programs.
• Ability to lead technical projects and collaborate across scientific disciplines.

Responsibilities

• Lead antibody and protein engineering programs, including affinity maturation, multispecific antibodies, and novel binder development.
• Develop protein expression, purification, and analytical characterization workflows across multiple formats.
• Design binding, biochemical, and functional assays to evaluate engineered candidates.
• Apply tools such as AlphaFold, Rosetta, and ProteinMPNN to prioritize designs and guide laboratory strategies.
• Partner with structural biologists and computational scientists to translate modeling insights into experimental programs.
• Provide technical leadership across complex, multidisciplinary research initiatives.
• Communicate findings, recommendations, and project progress to scientific stakeholders.

Skills

Antibody engineering

Protein engineering

Expression & purification

Assay development

Computational design

Leadership

Education

PhD in biochemistry or related discipline

Tools

AlphaFold

Rosetta

ProteinMPNN

Job description

Gables Search Group is assisting a research-driven biotechnology organization in Rockville, MD to hire a Computational Protein Engineer who will lead hands-on antibody and protein engineering programs, integrating wet-lab experimentation with computational design to accelerate discovery.

You will apply AlphaFold, Rosetta, and ProteinMPNN, collaborate with structural biologists and chemists, and communicate progress to stakeholders while shaping long-term research impact.