Lead, Computational Biology & Protein Design

Institute for Protein Innovation; Boston (MA); On-site; USD 200,000 - 240,000; Full time

Benefits offered by this job

Medical, dental, vision plans

401(k) with 6% match

Paid time off

Commuter and parking reimbursement

Career development opportunities

Job summary

The Institute for Protein Innovation (IPI) in Boston is seeking a Computational Biology & Bioinformatics Lead to grow our computational protein science team. You will train and deploy foundation models for protein folding, design, and discovery, while guiding model development with multimodal data across sequence, structure, and assays.

You will manage a small team, collaborate with the Antibody Platform leadership, and drive data-driven decision making, publications, and platform development in

Qualifications

• PhD in computational biology, bioinformatics, biophysics, machine learning, or related field with protein science/biochemistry background.
• At least 5 years of relevant experience, including leading or mentoring computational staff; prior experience managing a small team is a plus.
• Strong Python skills and hands-on experience with deep learning frameworks such as PyTorch.

Responsibilities

• Train, fine-tune, and benchmark foundation models for protein folding, design, and antibody discovery; integrate models for routine use.
• Build and validate models predicting stability, aggregation, expression, binding affinity and developability using multimodal data.
• Run in silico binder and antibody design campaigns and pair with experimental rounds for feedback.

Skills

PhD in computational biology

Team leadership

Python

PyTorch

Multimodal data

Protein ML

De novo design

Education

PhD in computational biology or related field

Tools

Cloud computing

GPU environments

Job description

The Institute for Protein Innovation (IPI) in Boston is seeking a Computational Biology & Bioinformatics Lead to grow our computational protein science team. You will train and deploy foundation models for protein folding, design, and discovery, while guiding model development with multimodal data across sequence, structure, and assays.

You will manage a small team, collaborate with the Antibody Platform leadership, and drive data-driven decision making, publications, and platform development in