Head of Computational Biology & Protein Design

Alta Resource Technologies, Inc.; Boulder (CO); On-site; USD 155,000 - 215,000; Full time

Benefits offered by this job

Flexible time off

Company holidays

Job summary

Alta Resource Technologies in Boulder, CO seeks a Head of Computational Biology to lead hands-on development and a small team. You will integrate DBTL data with in silico and bioinformatics to improve protein expression, activity, and manufacturability.

Translate computational models into experimentally validated candidates, define scalable workflows with data quality and provenance, and collaborate across biology, data science, and software groups to drive toward commercialization.

Qualifications

• Ph.D. in computational biology or related field.
• 5–10 years of cross-functional leadership experience.
• Proven track record delivering protein/peptide/antibody candidates toward commercialization.
• Expertise in machine learning and predictive models for protein engineering.
• Experience with bioinformatics pipelines and databases.
• Experience with generative AI models.
• Experience with molecular dynamics and quantum mechanics parameterization.
• Experience with LIMS and sample management systems.
• Strong written and verbal communication skills.

Responsibilities

• Lead a group to develop model classifications and scoring using in silico and real-world data sources.
• Establish protein/peptide MD and quantum mechanics workflows for in silico scoring.
• Contribute hands-on to model development, code, and analysis with the team.
• Define success metrics tied to experimentally confirmed hits and manufacturable leads.
• Build pipelines from existing sequence databases and 3D modeling data.
• Collaborate with data science to implement genotype-to-phenotype tracking for learning cycles.
• Build a world-class tracking system for proteins across design, build, test, and scale workflows.
• Lead talent development and mentor a small team of computational scientists.

Skills

People leadership

Machine learning

Bioinformatics

Generative AI

Molecular dynamics

Quantum mechanics

LIMS

Data pipelines

Communication

Documentation

Education

Ph.D. in computational biology

Tools

Git

AWS

LIMS

Protein design tools

Job description

Alta Resource Technologies in Boulder, CO seeks a Head of Computational Biology to lead hands-on development and a small team. You will integrate DBTL data with in silico and bioinformatics to improve protein expression, activity, and manufacturability.

Translate computational models into experimentally validated candidates, define scalable workflows with data quality and provenance, and collaborate across biology, data science, and software groups to drive toward commercialization.