Lead cfDNA Bioinformatics Scientist – Algorithms & Pipelines

Embedded Shishya; United States; Remote; USD 131,000 - 164,000; Full time

Benefits offered by this job

Competitive benefits

Job summary

Natera is seeking a Lead Bioinformatician to advance algorithmic foundations for diagnostic assays, focusing on cfDNA analysis in women's and organ health. This individual contributor role calls for deep genomics expertise and scalable computational tools to extract reliable signals from sequencing data.

Responsibilities span panel science, caller strategy, and data quality, with collaboration across Product, Laboratory Directors, and Research. Strong Python and regulatory experience are valued.

Qualifications

• Degree in Bioinformatics, Computational Biology, or related field.
• 4+ years analyzing short-read sequencing data for screening or diagnostic applications in regulated settings.
• Experience contributing to bioinformatics workflows behind a sequencing assay or panel.
• Experience seeing a complex investigation through to resolution across biological, analytical, and system-level causes.

Responsibilities

• Panel and Assay Science: provide genomics algorithm insights for panel roadmap and analytical approaches.
• Caller Strategy and Method Development: define computational strategy for new callers and prototype/benchmark methods.
• Scientific Investigation and Escalation: act as genomics consultant in production escalations and distinguish biological from analytical issues.
• Data Quality and Cross-functional Partnership: liaise with Variant Management, Reporting, and Laboratory Operations on data quality and variant representation.
• Ways of Working: help define what correct looks like for AI-assisted investigation and ramp time for tools.

Skills

Bioinformatics

Python

Genomics

Data analysis

Education

Bioinformatics degree

Tools

Genomics pipelines

Variant calling tools

Job description

Natera is seeking a Lead Bioinformatician to advance algorithmic foundations for diagnostic assays, focusing on cfDNA analysis in women's and organ health. This individual contributor role calls for deep genomics expertise and scalable computational tools to extract reliable signals from sequencing data.

Responsibilities span panel science, caller strategy, and data quality, with collaboration across Product, Laboratory Directors, and Research. Strong Python and regulatory experience are valued.