Lead Bioinformatics Manager — Oncology Diagnostics

Natera; San Carlos (CA); On-site; USD 154,000 - 192,500; Full time

Benefits offered by this job

Annual bonus

Long-term equity awards

401(k) with company match

Generous paid time off and holidays

Wellness programs

Job summary

Natera is a global leader in cfDNA testing, dedicated to oncology, women’s health and organ health. We seek a Bioinformatics Manager to lead the Bioinformatics team focused on Oncology Product Development and to manage a group of bioinformaticians and data scientists in the design, development and validation of ctDNA-based tests.

Collaboration across biostatistics, molecular biology, software engineering and commercial departments is essential.

Qualifications

• Postgraduate data science and/or bioinformatics experience (4–8+ years).
• 1–3 years in a technical lead role in diagnostics or related field.
• Experience moving algorithm-based products through commercialization and launch.
• Strong Python/R and ML foundation; solid statistics and modeling understanding.

Responsibilities

• Lead the development, optimization, and improvement of tools and analysis pipelines for diagnostic tests, including detection of cancer-associated variants or methylation patterns and setting evidence-based quality control thresholds.
• Provide technical leadership for product development projects by representing the team in cross-functional interactions and advancing products from research through commercial launch.
• Supervise bioinformatics scientists and data scientists, manage technical contributions, prioritize resources, and develop team members.
• Provide input on experimental design, analysis and interpretation based on expertise in Natera’s technology and relevant mathematical principles.
• Operate with a high level of independence and responsibility in carrying out assignments.
• Contribute to the company’s intellectual property portfolio.
• Set standards for rigorous data analysis and lead the production of high-quality documentation.

Skills

Python

R

Biostatistics

Machine Learning

Team Leadership

Data Visualization

DNA methylation analysis

Tools

NGS analysis tools

Clinical diagnostics

Job description

Natera is a global leader in cfDNA testing, dedicated to oncology, women’s health and organ health. We seek a Bioinformatics Manager to lead the Bioinformatics team focused on Oncology Product Development and to manage a group of bioinformaticians and data scientists in the design, development and validation of ctDNA-based tests.

Collaboration across biostatistics, molecular biology, software engineering and commercial departments is essential.