Lead Bioinformatics & ML Scientist, Epigenomics Oncology (Remote)

Natera, Inc.; United States; Remote; USD 146,000 - 180,000; Full time

Job summary

Natera, Inc. is seeking a Lead Bioinformatics & Machine Learning Scientist to advance Epigenomics in Oncology within our Bioinformatics R&D team. You will develop ML methods for early cancer detection from cfDNA methylation data and provide technical leadership in a highly collaborative setting.

The role emphasizes mentoring, design reviews, and collaboration with molecular biologists to ensure data integrity and impactful biomarkers. Remote-friendly with competitive benefits.

Qualifications

• PhD with 4–8+ years post-PhD experience in relevant quantitative field.
• Hands-on cancer genomics/epigenomics experience; cfDNA or methylation data is a plus.
• Strong quantitative reasoning and applied ML background; deep learning a plus.
• Proven track record developing computational methods for high-throughput sequencing data.
• Strong programming in Python and scientific libraries (pandas, NumPy, scikit-learn).
• Experience with Linux, shell scripting, Git, and workflow managers; cloud/HPC exposure.
• Ability to perform hypothesis-driven research and present results clearly.
• Experience mentoring or leading scientists.

Responsibilities

• Drive technical workstreams from problem definition to classifier delivery.
• Design, implement, and validate ML/statistical methods for cancer diagnostics.
• Promote best practices in interpretability, uncertainty, and reproducibility.
• Design robust pipelines for cfDNA methylation and sequencing data.
• Collaborate with molecular biologists on experimental design and QC.
• Mentor scientists and participate in code/design reviews.

Skills

PhD in Bioinformatics/CompSci/ML

Machine learning & statistics

Genomics/epigenomics analysis

cfDNA methylation data analysis

Python & scientific stack

Linux CLI & scripting

Workflow managers (Nextflow/Snakemake)

Git/version control

Cloud/HPC compute experience

Mentoring/technical leadership

Education

PhD in Bioinformatics, Computer Science, ML, Statistics or related field

Tools

Nextflow

Snakemake

Git

Python (NumPy, pandas, scikit-learn)

Linux shell

Job description

Natera, Inc. is seeking a Lead Bioinformatics & Machine Learning Scientist to advance Epigenomics in Oncology within our Bioinformatics R&D team. You will develop ML methods for early cancer detection from cfDNA methylation data and provide technical leadership in a highly collaborative setting.

The role emphasizes mentoring, design reviews, and collaboration with molecular biologists to ensure data integrity and impactful biomarkers. Remote-friendly with competitive benefits.