Lead Bioinformatics ML Scientist – Epigenomics & cfDNA (Remote)

Aimlroles; United States; Remote; USD 146,000 - 180,000; Full time

Job summary

Natera is seeking a Lead Bioinformatics & Machine Learning Scientist to advance R&D in Epigenomics for oncology, focusing on cfDNA methylation data. You will develop and deploy ML methods for early cancer detection and provide technical leadership within a collaborative team.

Ideal candidates have a PhD with 4–8+ years in genomics/ML, strong Python skills, and experience mentoring others. Remote USA options are available with a competitive compensation package.

Qualifications

• PhD in Bioinformatics, CS, ML, Statistics or related field with 4–8+ years post-PhD experience.
• Hands-on cancer genomics or epigenomics experience; cfDNA methylation sequencing a plus.
• Strong foundation in quantitative reasoning, statistics, and applied ML; deep learning exp. a plus.
• Proven track record of developing computational methods for HTS data analysis.
• Strong programming skills in Python and its stack (pandas, NumPy, scikit-learn).
• Experience with Linux CLI, shell scripting, Git, workflow managers (Nextflow, Snakemake) and cloud/HPC environments.
• Ability to perform hypothesis-driven research, visualize findings, and summarize results orally and in writing.
• Experience mentoring or leading other scientists.

Responsibilities

• Drive technical workstreams from problem definition to delivery of final classifiers.
• Design and validate novel ML/statistical methods for cancer diagnostics.
• Promote best practices in model interpretability, uncertainty estimation, and reproducibility.
• Design robust feature extraction pipelines for cfDNA methylation and sequencing data.
• Collaborate with molecular biologists on experimental design and data quality.
• Mentor scientists and foster innovation, collaboration, and scientific excellence.
• Lead and participate in code and design reviews.

Skills

Statistical reasoning

Machine learning

Applied ML

Oral/written communication

Education

PhD in Bioinformatics/CS/ML/Statistics

Tools

Python

Linux

Git

Nextflow

Snakemake

Job description

Natera is seeking a Lead Bioinformatics & Machine Learning Scientist to advance R&D in Epigenomics for oncology, focusing on cfDNA methylation data. You will develop and deploy ML methods for early cancer detection and provide technical leadership within a collaborative team.

Ideal candidates have a PhD with 4–8+ years in genomics/ML, strong Python skills, and experience mentoring others. Remote USA options are available with a competitive compensation package.