Lead Bioinformatics & ML Scientist (Remote)

Natera; United States; Remote; USD 146,000 - 182,000; Full time

Job summary

Natera is seeking a Lead Bioinformatics & Machine Learning Scientist to join our Bioinformatics Research team and help build the machine learning models behind our tissue-free, methylation-based assay. These models will support cancer detection in the MRD setting and inform treatment decisions.

The ideal candidate brings a strong background in algorithm development, genomics, sequencing data processing, and applied machine learning, with experience collaborating across computational and

Qualifications

• PhD in a quantitative field with 4–8+ years of post-PhD experience.
• Strong background in cancer epi/genomics and high-throughput sequencing data analysis.
• Experience with Python and Linux command-line tools, including shell scripting.

Responsibilities

• Develop, train, and evaluate ML models to detect cancer in MRD.
• Own end-to-end research analyses from ideation to implementation and evaluation.
• Bridge wet-lab design and computational analysis, ensuring QC across data.
• Communicate findings and establish standards for reproducibility.

Skills

DNA sequencing data analysis

Sequence alignment

Variant calling

Machine learning model development

Python

Linux CLI

Python data libraries

Education

PhD in Computer Science / Bioinformatics

Tools

Shell scripting

Git

High-performance computing

Job description

Natera is seeking a Lead Bioinformatics & Machine Learning Scientist to join our Bioinformatics Research team and help build the machine learning models behind our tissue-free, methylation-based assay. These models will support cancer detection in the MRD setting and inform treatment decisions.

The ideal candidate brings a strong background in algorithm development, genomics, sequencing data processing, and applied machine learning, with experience collaborating across computational and