Lead Bioinformatics & ML Scientist - Cancer Epigenomics

Royper Royco LLC; United States; Remote; USD 146,000 - 180,000; Full time

Benefits offered by this job

Competitive benefits

Free testing for dependents

Fertility care benefits

401k benefits

Commuter benefits

Employee referral program

Job summary

Natera seeks a Lead Bioinformatics & Machine Learning Scientist to advance R&D in Epigenomics for oncology. You will develop ML methods for early cancer detection from cfDNA methylation data and provide technical leadership within a collaborative team.

The role emphasizes designing novel algorithms, driving validation, mentoring others, and ensuring rigorous, reproducible research across computational and experimental workflows.

Qualifications

• PhD in Bioinformatics, Computer Science, Machine Learning, Statistics, or related quantitative field.
• Hands-on experience in cancer genomics or epigenomics; cfDNA methylation sequencing data is a plus.
• Strong quantitative reasoning, statistical analysis, and applied ML.
• Proven track record of developing computational methods for high-throughput sequencing data analysis.

Responsibilities

• Drive technical workstreams from problem definition to final classifiers and downstream validation.
• Design, implement, and validate novel ML and statistical methods for cancer diagnostics.
• Promote best practices in model interpretability, uncertainty estimation, and reproducibility.
• Design robust feature engineering pipelines for cfDNA methylation and sequencing data.
• Collaborate with molecular biologists on experimental design; ensure data integrity and quality control.
• Mentor scientists and foster a culture of innovation and collaboration.
• Lead and participate in code and design reviews.

Skills

Python stack (pandas, NumPy, scikit-le

ML for genomics

Linux command line

Git version control

Workflow management (Nextflow, Snakem

Cloud/HPC compute environments

Hypothesis-driven research

Education

PhD in Bioinformatics/CS/ML/Statistics

Tools

Nextflow

Snakemake

Python

Job description

Natera seeks a Lead Bioinformatics & Machine Learning Scientist to advance R&D in Epigenomics for oncology. You will develop ML methods for early cancer detection from cfDNA methylation data and provide technical leadership within a collaborative team.

The role emphasizes designing novel algorithms, driving validation, mentoring others, and ensuring rigorous, reproducible research across computational and experimental workflows.