Bioinformatics Manager (Oncology Product Development)

Natera; San Carlos (CA); On-site; USD 154,000 - 192,500; Full time

Benefits offered by this job

Annual bonus

Long-term equity awards

401(k) with company match

Generous paid time off and holidays

Wellness programs

Job summary

Natera is a global leader in cfDNA testing, dedicated to oncology, women’s health and organ health. We seek a Bioinformatics Manager to lead the Bioinformatics team focused on Oncology Product Development and to manage a group of bioinformaticians and data scientists in the design, development and validation of ctDNA-based tests.

Collaboration across biostatistics, molecular biology, software engineering and commercial departments is essential.

Qualifications

• Postgraduate data science and/or bioinformatics experience (4–8+ years).
• 1–3 years in a technical lead role in diagnostics or related field.
• Experience moving algorithm-based products through commercialization and launch.
• Strong Python/R and ML foundation; solid statistics and modeling understanding.

Responsibilities

• Lead the development, optimization, and improvement of tools and analysis pipelines for diagnostic tests, including detection of cancer-associated variants or methylation patterns and setting evidence-based quality control thresholds.
• Provide technical leadership for product development projects by representing the team in cross-functional interactions and advancing products from research through commercial launch.
• Supervise bioinformatics scientists and data scientists, manage technical contributions, prioritize resources, and develop team members.
• Provide input on experimental design, analysis and interpretation based on expertise in Natera’s technology and relevant mathematical principles.
• Operate with a high level of independence and responsibility in carrying out assignments.
• Contribute to the company’s intellectual property portfolio.
• Set standards for rigorous data analysis and lead the production of high-quality documentation.

Skills

Python

R

Biostatistics

Machine Learning

Team Leadership

Data Visualization

DNA methylation analysis

Tools

NGS analysis tools

Clinical diagnostics

Job description

Bioinformatics Manager (Oncology Product Development)

Natera is seeking a Bioinformatics Manager to lead the Bioinformatics team focused on Oncology Product Development. The role involves managing a team of bioinformaticians and data scientists and providing technical leadership in the design, development and validation of ctDNA-based diagnostic tests. This position requires collaboration across biostatistics, molecular biology, software engineering and commercial departments. The ideal candidate will have strong bioinformatics and data science expertise, with experience in analysis or modeling of DNA methylation data and a track record of project and technical leadership.

Responsibilities

• Lead the development, optimization, and improvement of tools and analysis pipelines for diagnostic tests, including detection of cancer-associated variants or methylation patterns and setting evidence-based quality control thresholds.
• Provide technical leadership for product development projects by representing the team in cross-functional interactions and advancing products from research through commercial launch.
• Supervise bioinformatics scientists and data scientists, manage technical contributions, prioritize resources, and develop team members.
• Provide input on experimental design, analysis and interpretation based on expertise in Natera’s technology and relevant mathematical principles.
• Operate with a high level of independence and responsibility in carrying out assignments.
• Contribute to the company’s intellectual property portfolio.
• Set standards for rigorous data analysis and lead the production of high-quality documentation.

Qualifications

• Minimum 4-8 years of postgraduate experience in a data science and/or bioinformatics role and 1-3 years as a technical lead in diagnostics or a related field.
• Experience moving algorithm-based products through commercialization and launch in medical or biological applications such as diagnostic testing, medical imaging, or biotechnology.

Desirable

• Prior experience analyzing or modeling DNA methylation data (not required).

Knowledge, Skills, and Abilities

• Experience using Python or R for scientific data analysis and visualization.
• Strong foundation in statistical modeling and machine learning, including probability theory and estimation/classification methods.
• Experience with analysis of next-generation sequencing data, including algorithm development or optimization.
• Ability to apply mathematical principles to solve real estimation problems and implement practical solutions.
• Excellent analytical, problem-solving and decision-making skills to independently make sound judgments and develop creative solutions to moderately complex problems.
• Experience leading technical projects, defining and meeting milestones, delegating tasks, and ensuring quality of deliverables.
• Excellent communication skills and the ability to work in a dynamic and collaborative environment.

Compensation & Total Rewards

This range reflects a good-faith estimate of base pay at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is eligible for additional compensation and benefits through Natera’s Total Rewards program, including:

• Annual performance incentive bonus
• Long-term equity awards
• 401(k) with company match
• Generous paid time off and company holidays
• Wellness and work-life benefits

Compensation Range: $154,000 - $192,500 USD

Our Opportunity

Natera is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. We aim to make personalized genetic testing and diagnostics part of standard care to protect health and enable earlier and more targeted interventions.

Our team comprises statisticians, geneticists, doctors, laboratory scientists, software engineers and other professionals from world-class institutions who care deeply about our work and each other. You’ll be challenged and grow quickly while contributing to changing the landscape of genetic disease management.

What We Offer

Competitive benefits including comprehensive medical, dental, vision, life and disability plans for employees and dependents. We offer fertility care benefits, pregnancy and bonding leave, 401(k) with company match, commuter benefits, and an employee referral program. Equal opportunity employer statement and commitment to diversity and inclusion are provided.

We encourage all qualified applicants to apply. Final hiring decisions are made without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or other legally protected status.

Equal Employment Opportunity

Natera is an Equal Opportunity Employer. We value diversity and inclusive collaboration to advance our mission of changing the management of disease worldwide.