Senior Proteomics Data Scientist, Platform Analytics

Madrona Venture Labs; San Carlos (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

Nautilus seeks a Senior Bioinformatics Scientist in San Carlos, CA, to translate complex proteomics data into actionable assay insights. You will partner with assay development, reagent, and platform scientists to design experiments, optimize assays, and understand results to guide decisions.

This role emphasizes cross-functional collaboration, data integration, and robust statistics. You will analyze data end-to-end, develop reusable tools, and communicate results to non-computational

Qualifications

• PhD in Bioinformatics, Computational Biology, Biostatistics, Biophysics, Chemistry, or related quantitative field.
• Minimum of 4 years of industry experience.
• Strong communication to explain technical findings to non-computational audiences.
• Hands-on experience with wet-lab data and assay development or optimization.
• Ability to trace complex data problems from raw data to root cause.
• Solid foundation in applied statistics and power/sensitivity analysis.
• Experience with Python data tools (pandas, NumPy, SciPy) and data visualization.
• Comfort with Linux, local/remote servers, and cloud environments (AWS).
• Experience with proteomics and moving assays from development to production.
• Experience building dashboards or interactive tools for non-technical users.

Responsibilities

• Partner with scientists to design and optimize proteoform and proteome assays built on Iterative Mapping.
• Analyze data end-to-end from run metadata to statistical conclusions and present results clearly.
• Improve assay reproducibility and quantitative accuracy.
• Guide experimental design, controls, replicates, and sample sizes; perform power analyses.
• Diagnose unexpected results and feed lessons learned into future designs.
• Develop and maintain QC metrics and reports with defensible thresholds.
• Access and integrate data from cloud warehouses, on-prem files, and experiment records.
• Convert recurring analyses into reusable software tools.
• Collaborate with chemists, engineers, and algorithm developers on project teams.

Skills

Python

Statistics

Data analysis

Communication

Experimental design

Education

PhD in Bioinformatics or related field

Tools

AWS

Linux

Git

SQL

Dash

Marimo

Job description

Nautilus seeks a Senior Bioinformatics Scientist in San Carlos, CA, to translate complex proteomics data into actionable assay insights. You will partner with assay development, reagent, and platform scientists to design experiments, optimize assays, and understand results to guide decisions.

This role emphasizes cross-functional collaboration, data integration, and robust statistics. You will analyze data end-to-end, develop reusable tools, and communicate results to non-computational