LC-MS/MS Project Chemist: Protein & Peptide Analysis

BioSpace; Houston (TX); On-site; USD 70,000 - 95,000; Full time

Job summary

Eagle Analytical is seeking a Project Chemist in Houston to support routine LC-MS–based analysis in a fast-paced laboratory. You will perform LC-MS/MS workflows, prepare samples, operate instruments, review data, and document results with minimal supervision.

The ideal candidate has hands-on LC-MS/MS experience, familiarity with GMP, and strong attention to detail. Join a collaborative team delivering high-quality analytical results on schedule.

Qualifications

• Bachelor's or master's degree in chemistry, analytical chemistry, biochemistry, or related field.
• Hands-on LC-MS/MS instrumentation and workflows experience.
• Mass spectrometry-based protein/peptide characterization experience preferred.
• LC-MS/MS quantitation using MRM and/or SIR modes preferred.

Responsibilities

• Perform routine LC-MS-based assays (peptide mapping, intact mass, protein/small molecule quantitation).
• Prepare samples, standards, mobile phases, buffers, and solutions.
• Operate and maintain LC-MS/MS and HPLC/UHPLC systems per SOPs.
• Conduct routine analytical runs and monitor instrument performance.
• Review, organize, and document analytical data and records.
• Identify unexpected results and provide initial troubleshooting.
• Perform system suitability, calibration, and QC checks.
• Troubleshoot basic instrument and method issues.
• Maintain laboratory cleanliness, inventory, and organization.
• Support method optimization and validation activities.
• Collaborate with cross-functional team to meet timelines.

Skills

LC-MS/MS

Sample preparation

Data review

Troubleshooting

Instrument maintenance

HPLC/UHPLC

Documentation

Team collaboration

Education

Bachelor's degree in Chemistry

Master's degree in Analytical Chemistry

Tools

MS data analysis software

HPLC control software

Job description

Eagle Analytical is seeking a Project Chemist in Houston to support routine LC-MS–based analysis in a fast-paced laboratory. You will perform LC-MS/MS workflows, prepare samples, operate instruments, review data, and document results with minimal supervision.

The ideal candidate has hands-on LC-MS/MS experience, familiarity with GMP, and strong attention to detail. Join a collaborative team delivering high-quality analytical results on schedule.