Project Chemist (Mass Spectrometry)

BioSpace; Houston (TX); On-site; USD 70,000 - 95,000; Full time

Job summary

Eagle Analytical is seeking a Project Chemist in Houston to support routine LC-MS–based analysis in a fast-paced laboratory. You will perform LC-MS/MS workflows, prepare samples, operate instruments, review data, and document results with minimal supervision.

The ideal candidate has hands-on LC-MS/MS experience, familiarity with GMP, and strong attention to detail. Join a collaborative team delivering high-quality analytical results on schedule.

Qualifications

• Bachelor's or master's degree in chemistry, analytical chemistry, biochemistry, or related field.
• Hands-on LC-MS/MS instrumentation and workflows experience.
• Mass spectrometry-based protein/peptide characterization experience preferred.
• LC-MS/MS quantitation using MRM and/or SIR modes preferred.

Responsibilities

• Perform routine LC-MS-based assays (peptide mapping, intact mass, protein/small molecule quantitation).
• Prepare samples, standards, mobile phases, buffers, and solutions.
• Operate and maintain LC-MS/MS and HPLC/UHPLC systems per SOPs.
• Conduct routine analytical runs and monitor instrument performance.
• Review, organize, and document analytical data and records.
• Identify unexpected results and provide initial troubleshooting.
• Perform system suitability, calibration, and QC checks.
• Troubleshoot basic instrument and method issues.
• Maintain laboratory cleanliness, inventory, and organization.
• Support method optimization and validation activities.
• Collaborate with cross-functional team to meet timelines.

Skills

LC-MS/MS

Sample preparation

Data review

Troubleshooting

Instrument maintenance

HPLC/UHPLC

Documentation

Team collaboration

Education

Bachelor's degree in Chemistry

Master's degree in Analytical Chemistry

Tools

MS data analysis software

HPLC control software

Job description

Job Details Description

What We Are Looking For

We are seeking a motivated Project Chemist to support routine LC-MS–based analysis in a fast-paced laboratory environment. This role is responsible for the timely and reliable execution of LC-MS/MS workflows, including sample preparation, instrument operation, troubleshooting, and data review. The ideal candidate is comfortable working with minimal supervision, maintaining instrument performance, and delivering high-quality analytical results in a timely manner.

What You Will Do

• Perform routine LC-MS based assays including peptide mapping, intact mass analysis and protein/small molecule quantitation in a timely and compliant manner
• Prepare samples, standards, mobile phases, buffers, and other laboratory solutions
• Operate and maintain LC-MS/MS and HPLC/UHPLC systems following SOPs
• Conduct routine analytical runs and monitor instrument performance
• Review, organize, interpret, and document analytical data and laboratory records
• Identify and report unexpected test results, providing initial troubleshooting where applicable.
• Perform system suitability, calibration, and QC checks
• Troubleshoot basic instrument and method issues
• Maintain laboratory cleanliness, inventory, and organization
• Support method optimization and validation activities as appropriate
• Collaborate with cross-functional team members to support project timelines and deliverables

Who You Are

• Bachelor’s or Master’s degree in chemistry, Analytical Chemistry, Biochemistry, or related field
• Hands‑on experience with LC-MS/MS instrumentation and workflows
• Experience with mass spectrometry–based protein and peptide characterization, including sample preparation, instrument operation, and data analysis, preferred
• Experience with LC-MS/MS quantitation using MRM and/or SIR acquisition modes preferred
• Hands‑on experience with HPLC or UHPLC systems
• Familiarity with biological and/or chemical sample matrices
• Experience with basic wet chemistry and sample preparation techniques
• Familiarity with GMP (Good Manufacturing Practices) and applicable regulatory requirements (e.g., FDA, ICH)
• Strong attention to detail, organizational skills, and documentation practices
• Comfortable working with laboratory software and data management systems
• Ability to work independently as well as collaboratively in a team environment
• Strong verbal and written communication skills

Preferred Experience

• Hands‑on experience with HPLC, UPLC, and MS instrumentation.
• Knowledge of peptide synthesis and purification techniques.
• Experience in a pharmaceutical or biotechnology setting.
• Understanding of protein chemistry and post‑translational modifications.

Who We Are

Serving customers since 2004, Eagle offers the highest quality in preparation testing for sterility, bacterial endotoxins, microbial detection, beyond‑use dating (BUD) determination and active ingredient potency. State‑of‑the‑art equipment, combined with the experience and knowledge of our team, makes Eagle the best choice for all testing needs. The Eagle team is committed not only to performing the best quality control testing but also working relentlessly with our customers on solutions if tests receive unexpected results. Learn more at www.eagleanalytical.com.

Qualifications Skills Preferred

Analytical Instrumentation Advanced

Behaviors Preferred

• Dedicated: Devoted to a task or purpose with loyalty or integrity
• Innovative: Consistently introduces new ideas and demonstrates original thinking
• Team Player: Works well as a member of a group
• Detail Oriented: Capable of carrying out a given task with all details necessary to get the task done well

Motivations Preferred

• Self‑Starter: Inspired to perform without outside help
• Job Security: Inspired to perform well by the knowledge that your job is safe
• Goal Completion: Inspired to perform well by the completion of tasks
• Growth Opportunities: Inspired to perform well by the chance to take on more responsibility

Education Preferred

• Bachelors or better in Analytical Chemistry or related field.
• Bachelors or better in Biochemistry or related field.
• Bachelors or better in Chemistry or related field.
• Masters or better in Analytical Chemistry or related field.
• Masters or better in Biochemistry or related field.
• Masters or better in Chemistry or related field.

Licenses & Certifications Preferred

• Certification in HPLC

Equal Opportunity Employer

This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.