LC-MS/MS Project Chemist

BioSpace; Houston (TX); On-site; USD 70,000 - 110,000; Full time

Job summary

Eagle seeks a Project Chemist to support routine LC-MS–based analyses in a fast-paced lab environment in Houston. You will handle sample prep, instrument operation, troubleshooting, and data review to ensure timely, high-quality results.

The role requires hands-on LC-MS/MS experience, HPLC/UHPLC proficiency, and familiarity with GMP requirements, with opportunities to contribute to method optimization and validation in a collaborative team setting.

Qualifications

• Bachelor’s or Master’s degree in chemistry, Analytical Chemistry, Biochemistry, or related field
• Hands-on experience with LC-MS/MS instrumentation and workflows
• Experience with mass spectrometry–based protein and peptide characterization, including sample preparation, instrument operation, and data analysis, preferred
• Experience with LC-MS/MS quantitation using MRM and/or SIR acquisition modes preferred
• Hands-on experience with HPLC or UHPLC systems
• Familiarity with biological and/or chemical sample matrices
• Experience with basic wet chemistry and sample preparation techniques
• Familiarity with GMP (Good Manufacturing Practices) and applicable regulatory requirements (e.g., FDA, ICH)
• Strong attention to detail, organizational skills, and documentation practices
• Comfortable working with laboratory software and data management systems
• Ability to work independently as well as collaboratively in a team environment
• Strong verbal and written communication skills

Responsibilities

• Perform routine LC-MS based assays including peptide mapping, intact mass analysis and protein/small molecule quantitation in a timely and compliant manner
• Prepare samples, standards, mobile phases, buffers, and other laboratory solutions
• Operate and maintain LC-MS/MS and HPLC/UHPLC systems following SOPs
• Conduct routine analytical runs and monitor instrument performance
• Review, organize, interpret, and document analytical data and laboratory records
• Identify and report unexpected test results, providing initial troubleshooting where applicable
• Perform system suitability, calibration, and QC checks
• Troubleshoot basic instrument and method issues
• Maintain laboratory cleanliness, inventory, and organization
• Support method optimization and validation activities as appropriate
• Collaborate with cross-functional team members to support project timelines and deliverables

Skills

Analytical Instrumentation

Education

Bachelor’s degree in Analytical Chemistry

Bachelor’s degree in Biochemistry

Bachelor’s degree in Chemistry

Master’s degree in Analytical Chemistry

Master’s degree in Biochemistry

Master’s degree in Chemistry

Job description

Eagle seeks a Project Chemist to support routine LC-MS–based analyses in a fast-paced lab environment in Houston. You will handle sample prep, instrument operation, troubleshooting, and data review to ensure timely, high-quality results.

The role requires hands-on LC-MS/MS experience, HPLC/UHPLC proficiency, and familiarity with GMP requirements, with opportunities to contribute to method optimization and validation in a collaborative team setting.