LC-MS/MS Project Chemist for Protein Analytics

RXinsider LTD.

Houston (TX)

On-site

USD 75,000 - 105,000

Full time

14 days+

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Job summary

Eagle Analytical is seeking a Project Chemist to support routine LC-MS–based analysis in a fast-paced lab. You will perform LC-MS/MS workflows, engaging in sample prep, instrument operation, troubleshooting, and data review to ensure timely, high-quality results.

The role requires hands-on LC-MS/MS and HPLC/UHPLC experience, familiarity with GMP and regulatory requirements, and the ability to work independently as well as in a team. Strong documentation and communication are essential.

Qualifications

Bachelor’s or Master’s degree in chemistry, analytical chemistry, biochemistry, or related field.
Hands‑on experience with LC‑MS/MS instrumentation and workflows.
Experience with mass spectrometry–based protein/peptide characterization preferred.
Experience with LC‑MS/MS quantitation using MRM and/or SIR preferred.
Hands‑on experience with HPLC or UHPLC systems.
Familiarity with GMP and regulatory requirements (FDA, ICH).

Responsibilities

Perform routine LC-MS based assays including peptide mapping, intact mass analysis and protein/small molecule quantitation.
Prepare samples, standards, mobile phases, buffers, and other laboratory solutions.
Operate and maintain LC-MS/MS and HPLC/UHPLC systems following SOPs.
Conduct routine analytical runs and monitor instrument performance.
Review, organize, interpret, and document analytical data and laboratory records.
Identify and report unexpected test results, providing initial troubleshooting where applicable.
Perform system suitability, calibration, and QC checks.
Troubleshoot basic instrument and method issues.
Maintain laboratory cleanliness, inventory, and organization.
Support method optimization and validation activities as appropriate.
Collaborate with cross-functional team members to support project timelines and deliverables.