Project Chemist — LC-MS & Protein/Peptide Analysis

Eagle; Houston (TX); On-site; USD 60,000 - 90,000; Full time

Job summary

Eagle is seeking a Project Chemist to support routine LC-MS–based analysis in a fast-paced laboratory. The role includes sample preparation, instrument operation, troubleshooting, and data review to ensure timely, high-quality analytical results.

The candidate will work with LC-MS/MS and HPLC/UHPLC systems, perform method validation activities as needed, and collaborate with cross-functional teams to meet project timelines in a GMP-aligned environment.

Qualifications

• Bachelor’s or Master’s degree in chemistry, analytical chemistry, biochemistry, or related field.
• Hands-on experience with LC-MS/MS instrumentation and workflows.
• Experience with mass spectrometry–based protein and peptide characterization, including sample prep, instrument operation, and data analysis, preferred.
• Experience with LC-MS/MS quantitation using MRM and/or SIR acquisition modes preferred.
• Hands-on experience with HPLC or UHPLC systems.
• Familiarity with biological and/or chemical sample matrices.
• Experience with basic wet chemistry and sample preparation techniques.
• Familiarity with GMP (Good Manufacturing Practices) and applicable regulatory requirements (e.g., FDA, ICH)
• Strong attention to detail, organizational skills, and documentation practices.
• Comfortable working with laboratory software and data management systems.
• Ability to work independently as well as collaboratively in a team environment.
• Strong verbal and written communication skills.

Responsibilities

• Perform routine LC-MS based assays including peptide mapping, intact mass analysis and protein/small molecule quantitation in a timely and compliant manner.
• Prepare samples, standards, mobile phases, buffers, and other laboratory solutions.
• Operate and maintain LC-MS/MS and HPLC/UHPLC systems following SOPs.
• Conduct routine analytical runs and monitor instrument performance.
• Review, organize, interpret, and document analytical data and laboratory records.
• Identify and report unexpected test results, providing initial troubleshooting where applicable.
• Perform system suitability, calibration, and QC checks.
• Troubleshoot basic instrument and method issues.
• Maintain laboratory cleanliness, inventory, and organization.
• Support method optimization and validation activities as appropriate.
• Collaborate with cross-functional team members to support project timelines and deliverables.

Skills

LC-MS/MS workflows

Data review & interpretation

Independent & collaborative work

Documentation practices

Attention to detail

Education

Bachelor’s or Master’s in Chemistry/Analytical Chemistry/Biochemistry

Tools

LC-MS/MS instrumentation

HPLC/UHPLC systems

Job description

Eagle is seeking a Project Chemist to support routine LC-MS–based analysis in a fast-paced laboratory. The role includes sample preparation, instrument operation, troubleshooting, and data review to ensure timely, high-quality analytical results.

The candidate will work with LC-MS/MS and HPLC/UHPLC systems, perform method validation activities as needed, and collaborate with cross-functional teams to meet project timelines in a GMP-aligned environment.