Innovative Protein Scientist - Transient Transfection

AlivaMab Biologics; San Diego (CA); On-site; USD 118,000 - 145,000; Full time

Job summary

AlivaMab Biologics seeks a Scientist to join the Protein Sciences team to design, optimize, and execute transient transfection workflows for antibodies and proteins in mammalian expression systems. You will drive developability and purification strategies while applying high-throughput automation and rigorous data analysis.

You will collaborate with colleagues across Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management to advance biologic formats from discovery

Qualifications

• Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or related field; 1–3 years of industry experience or MS with 5–7 years.
• Proven hands-on experience with multiple mammalian expression platforms.
• Experience with AKTA purification and QC techniques.
• Strong analytical, troubleshooting, and communication skills.

Responsibilities

• Independently design and execute transient transfection workflows for antibodies and proteins in various mammalian expression systems.
• Provide leadership in protein purification by designing and improving methods for throughput, quality, and efficiency.
• Drive developability assessment efforts by designing and executing analytical studies to evaluate protein stability, purity, and key biophysical characteristics.
• Support production of complex construct design strategies (e.g., VLPs, nanodiscs), to enable immunization of challenging targets.
• Execute high throughput processes to support protein production workflows using Bravo and other robotic platforms.
• Effectively maintain meticulous records of lab activities using electronic notebook (Benchling); communicate findings clearly through written reports and presentations to support project progression and scientific decision-making.
• Contribute innovative ideas and collaborate effectively across teams to drive research excellence and project success in a fast-paced environment.

Skills

Mammalian expression platforms

Biophysical characterization

Analytical troubleshooting

Scientific communication

Education

Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or related field

MS in related field with 5–7 years industry experience

Tools

AKTA system

HIC/SEC/Affinity chromatography

Benchling

Job description

AlivaMab Biologics seeks a Scientist to join the Protein Sciences team to design, optimize, and execute transient transfection workflows for antibodies and proteins in mammalian expression systems. You will drive developability and purification strategies while applying high-throughput automation and rigorous data analysis.

You will collaborate with colleagues across Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management to advance biologic formats from discovery