In Vivo Oncology Research Associate

Pattern Biosciences; South San Francisco (CA); On-site; USD 120,000 - 170,000; Full time

Job summary

Pattern Bio in South San Francisco seeks an experienced in vivo scientist to advance our AAV-based cancer therapies. You will design and execute preclinical studies with a focus on rigor and regulatory compliance within a cross-disciplinary team.

You will plan and perform in vivo murine studies, including surgeries, dosing, tumor monitoring, tissue processing and data analysis, contributing to the oncology pipeline at Pattern Bio.

Qualifications

• MSc in life sciences.
• At least 3 years of hands-on experience with murine oncology models.
• Hands-on experience with complex rodent procedures including thoracic or abdominal surgery, suturing and wound closure, and tail vein dosing.
• Experience in necropsy, tissue handling and processing, tumor cell and splenocyte isolation, and flow cytometry.
• Detail-oriented with strong organizational and record-keeping skills.
• Excellent communication and ability to collaborate in a cross-functional team.
• Experience in a GLP or regulatory-compliant environment is a plus.

Responsibilities

• Plan and execute in vivo studies in collaboration with discovery and data scientists.
• Perform various in vivo procedures in mice: dosing via IV, IP and SC, blood sampling, and complex surgeries to establish orthotopic tumor models.
• Monitor tumor volume by in vivo imaging or caliper measurement and conduct necropsy and tissue processing.
• Perform mammalian cell culture and QC for in vivo experiments.
• Generate, document and analyze in vivo study data in accordance with protocols, SOPs and regulations.
• Interface with external laboratories and partners.

Skills

Murine oncology models

Complex rodent procedures

Suturing & wound closure

Tail vein dosing

Necropsy & tissue handling

Flow cytometry

Documentation & record-keeping

Cross-functional collaboration

Education

MSc in life sciences

Tools

MACS

FACS

Job description

Pattern Bio in South San Francisco seeks an experienced in vivo scientist to advance our AAV-based cancer therapies. You will design and execute preclinical studies with a focus on rigor and regulatory compliance within a cross-disciplinary team.

You will plan and perform in vivo murine studies, including surgeries, dosing, tumor monitoring, tissue processing and data analysis, contributing to the oncology pipeline at Pattern Bio.