In Vivo Oncology Pharmacology Postdoctoral Fellow

CU Denver; Aurora (CO); Vor Ort; USD 63.000 - 77.000; Vollzeit

Zusammenfassung

University of Colorado Anschutz Medical Campus invites applications for a full-time Postdoctoral Fellow in the Department of Pharmaceutical Sciences. The successful candidate will contribute to a federally funded translational oncology program focused on preclinical development of small-molecule therapeutics for colorectal cancer, with hands-on experience in in vivo pharmacology and mouse efficacy studies.

The role involves designing CDX and PDX studies, administering therapies via PO, IP, and

Qualifikationen

• PhD, MD, DVM, or equivalent doctoral degree in pharmacology, pharmaceutical sciences, cancer biology, molecular or cellular biology, translational biomedical sciences, or closely related field.
• Demonstrated hands-on experience designing and conducting mouse in vivo pharmacology or therapeutic efficacy studies.
• Demonstrated experience with mouse tumor xenograft models, including CDX and PDX.
• Demonstrated proficiency in mouse handling, restraint, health monitoring, and animal welfare procedures.
• Demonstrated proficiency administering drugs to mice by oral gavage, intraperitoneal injection, and intravenous tail-vein injection.
• Experience independently collecting, analyzing, interpreting, and documenting data from animal studies.

Aufgaben

• Design, plan, and execute in vivo pharmacology and therapeutic efficacy studies in mouse models of colorectal cancer.
• Establish and conduct CDX and PDX studies, including tumor implantation, growth monitoring, randomization, treatment, and study endpoints.
• Administer investigational therapeutics via PO, IP, and IV, including repeated-dose regimens.
• Perform routine mouse handling and health monitoring across sex; monitor body weight and humane endpoints.
• Collect tissues; support necropsy and tissue processing; assist downstream histologic and molecular analyses.
• Analyze data, maintain study records, and prepare figures, presentations, and manuscripts.
• Collaborate with academic and industry investigators to develop protocols and troubleshoot studies.

Kenntnisse

In vivo pharmacology

Mouse handling

Data interpretation

Experimental design

Scientific communication

Ausbildung

PhD, MD, DVM, or equivalent doctoral degree

Tools

CDX models

PDX models

Orthotopic models

Mouse handling & dosing methods

Jobbeschreibung

University of Colorado Anschutz Medical Campus invites applications for a full-time Postdoctoral Fellow in the Department of Pharmaceutical Sciences. The successful candidate will contribute to a federally funded translational oncology program focused on preclinical development of small-molecule therapeutics for colorectal cancer, with hands-on experience in in vivo pharmacology and mouse efficacy studies.

The role involves designing CDX and PDX studies, administering therapies via PO, IP, and