Imaging Scientist - Tissue Pathology & Biomarker Discovery

Amgen Inc. (IR); South San Francisco (CA); On-site; USD 129,000 - 175,000; Full time

Job summary

Amgen is seeking a Scientist to join the Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) Department in South San Francisco, California. The Scientist will develop and apply tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy, and biomarker discovery.

You will collaborate with pathologists, research investigators, and translational teams to deliver

Qualifications

• Experience analyzing pathology imaging data, including H&E, IHC, multiplex immunofluorescence, and/or spatial transcriptomics.
• Familiarity with whole-slide imaging and digital pathology platforms, such as HALO or Visiopharm, is preferred.
• Understanding of machine-learning methods for image segmentation, classification, detection, and representation learning.
• Strong communication, organizational, and collaboration skills in multidisciplinary scientific environments.

Responsibilities

• Develop, optimize, validate, and standardize histopathology assays using FFPE samples, including single-plex and multiplex IHC and ISH in colorimetric and immunofluorescent formats.
• Use imaging modalities and digital pathology tools to generate, analyze, and interpret tissue-based data for target qualification, pharmacodynamic and efficacy assessments, and biomarker development.
• Collaborate with pathologists, research investigators, and translational teams to deliver high-quality data supporting mechanism-of-action studies, in vivo model development, and toxicity assessments across therapeutic areas.
• Maintain clear, complete documentation and communicate results through laboratory information systems, databases, and team presentations.

Skills

Image analysis

Strong communication

Collaboration

Education

PhD in biology

Master's in biology

Bachelor's in biology

Tools

HALO

Visiopharm

Ventana

Leica Bond

IntelliPATH

Job description

Amgen is seeking a Scientist to join the Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) Department in South San Francisco, California. The Scientist will develop and apply tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy, and biomarker discovery.

You will collaborate with pathologists, research investigators, and translational teams to deliver