Hybrid Research Associate, Manufacturing Process

Ionis Pharmaceuticals, Inc.; Carlsbad (CA); On-site; USD 69,000 - 110,000; Full time

Job summary

Ionis Pharmaceuticals, Inc. in Carlsbad, CA, is seeking a Research Associate I/II in Manufacturing Process Research to support lab-scale oligonucleotide manufacturing.

You will perform solid-phase synthesis, purification, and analytical testing under guidance, document results, and contribute to development reports while collaborating with Manufacturing, Analytical Development, and Quality teams. The role emphasizes careful data recording, safety, and the ability to learn new chemistries and

Qualifications

• Bachelor’s degree in chemistry or related field with relevant lab experience.
• Ability to follow procedures and maintain records.
• Strong attention to detail and data integrity.
• Willingness to work in a cross-functional team.
• Comfort working with hazardous chemicals and GMP-like environments.

Responsibilities

• Execute defined lab experiments supporting oligonucleotide process development.
• Perform solid-phase synthesis and related operations.
• Prepare, purify, and analyze oligonucleotide materials.
• Document results in electronic notebook and reports.
• Collaborate with cross-functional teams to advance programs.
• Maintain safety and compliance in the lab.
• Support investigations and resolve deviations.

Skills

Attention to detail

Data integrity

Analytical thinking

Effective communication

Team collaboration

Written reporting

Education

Bachelor’s degree in chemistry or related scientific field

Tools

HPLC

LC-MS

UV detection

Electronic lab notebook

Job description

Ionis Pharmaceuticals, Inc. in Carlsbad, CA, is seeking a Research Associate I/II in Manufacturing Process Research to support lab-scale oligonucleotide manufacturing.

You will perform solid-phase synthesis, purification, and analytical testing under guidance, document results, and contribute to development reports while collaborating with Manufacturing, Analytical Development, and Quality teams. The role emphasizes careful data recording, safety, and the ability to learn new chemistries and