Head of DNA-Encoded Library Discovery

Takeda; Boston (MA); On-site; USD 177,000 - 278,000; Full time

Job summary

Takeda in Boston, MA seeks Head of DNA-Encoded Library to lead DEL strategy and in-house screening. You will build a team, design DEL libraries, oversee selections, data analysis, and hit-to-lead progression, collaborating across disciplines to translate DEL insights into actionable chemistry and project decisions.

The role requires deep on-DNA chemistry expertise, DEL platform development, and strong leadership.

Qualifications

• Deep expertise in DEL platform development and on-DNA chemistry.
• Ability to translate DEL insights into actionable decisions.
• Experience leading cross-functional discovery teams.

Responsibilities

• Define and implement DEL screening strategies.
• Build in-house DEL capability and team.
• Design, synthesize and assess DEL libraries.
• Oversee DEL selection campaigns and data analysis.
• Lead hit triage and hit-to-lead activities.
• Collaborate with chem, biology, biophysics, and project teams.
• Mentor scientists and promote a rigorous scientific culture.

Skills

DEL library design

On-DNA chemistry

Data analysis

Cross-functional leadership

Scientific communication

Education

PhD in Chemistry or related

MS with 16+ years experience

Job description

Takeda in Boston, MA seeks Head of DNA-Encoded Library to lead DEL strategy and in-house screening. You will build a team, design DEL libraries, oversee selections, data analysis, and hit-to-lead progression, collaborating across disciplines to translate DEL insights into actionable chemistry and project decisions.

The role requires deep on-DNA chemistry expertise, DEL platform development, and strong leadership.