Genome Editing Scientist--Bioinformatics

Missouri Ag Connection; Chesterfield, Northern (MO, KY); Hybrid; USD 97,000 - 146,000; Full time

Benefits offered by this job

Health care

Vision

Dental

Retirement

PTO

Sick leave

Job summary

Bayer is seeking a Genome Editing Scientist–Bioinformatics in Chesterfield, MO to build reproducible data pipelines and predictive models for CRISPR-based editing. You will work with molecular biology and structural biology colleagues to translate biological questions into computational strategies and to connect predictions with experiments.

The role requires strong Python/R skills, experience with NGS data and genome editing analyses, and the ability to communicate results clearly to

Qualifications

• PhD in bioinformatics, computational biology, genomics, or a related field, or a Master’s degree with 3+ years of experience.
• Strong programming skills in Python and R and ability to write maintainable, well-documented code.
• Experience analyzing genome editing NGS datasets (amplicon/targeted sequencing) and interpreting results for CRISPR-Cas.
• Knowledge of statistical methods for editing precision and efficiency; ability to communicate assumptions clearly.
• Experience with plant functional genomics analyses and integrating multi-omics signals.
• Strong communication and collaboration skills across multidisciplinary teams.

Responsibilities

• Build and maintain reproducible pipelines and integrated datasets to evaluate editing tool performance.
• Develop statistical and ML models to quantify drivers of editing efficiency and compare tool variants.
• Design computational approaches to improve editing component design (guide/target selection).
• Analyze large-scale sequencing data to characterize editing outcomes and generate summaries.
• Collaborate with molecular/structural biology teams to translate data into actionable recommendations.
• Coordinate with genomics and data science stakeholders to ensure scalable pipelines.

Skills

Python

R

NGS data analysis

CRISPR-Cas

Education

PhD in bioinformatics/computational biology/genomics or related (or Master’s +3 years)

Tools

HPC

Git

Job description

At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none' is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining 'impossible'. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice.

Genome Editing Scientist--Bioinformatics

You will enable data-driven decisions on target selection, experimental design, and editing outcome interpretation by developing reproducible analyses, predictive models, and clear visualizations; You will partner closely with molecular and structural biology colleagues to translate biological questions into computational strategies and to connect prediction with experimental validation.

YOUR TASKS AND RESPONSIBILITIES

The primary responsibilities of this role are to:

• Build and maintain reproducible pipelines and integrated datasets (e.g., sequence, accessibility/expression, structure) to evaluate and optimize editing tool performance across germplasm and testing systems;
• Develop and apply statistical and machine learning models and metrics to quantify drivers of editing efficiency and precision and to compare tool variants across genomic contexts;
• Develop computational approaches to improve the design of precise editing components, including guide and target selection and constraint-aware design;
• Analyze large-scale sequencing datasets to characterize editing outcomes, fidelity, and error modes, and generate clear visualizations and decision-ready summaries;
• Partner with molecular and structural biology teams to design experiments, define analysis plans, and translate multi-modal data into actionable recommendations for tool development;
• Collaborate closely with genomics, functional genomics, and digital/data science stakeholders to ensure that tools, pipelines, and analyses are scalable, robust, and aligned with broader platform needs.

WHO YOU ARE

Bayer seeks an incumbent who possesses the following:

Required Qualifications

• PhD in bioinformatics, computational biology, genomics, or a related field, or a Master’s degree with 3+ years of additional relevant experience;
• Strong programming skills in languages relevant to biological data analysis (e.g., Python, R) and ability to write maintainable, well-documented code;
• Experience analyzing genome editing NGS datasets (e.g., amplicon or targeted sequencing) and interpreting results in the context of CRISPR-Cas and related editing technologies;
• Knowledge of statistical methods for analyzing editing precision and efficiency, and ability to clearly communicate underlying assumptions and limitations;
• Experience with plant functional genomics analyses (e.g., differential expression) and ability to integrate multi-omics signals for hypothesis generation;
• Strong communication and collaboration skills, including the ability to translate computational results for diverse audiences and to work effectively across multidisciplinary teams.

Preferred Qualifications

• Experience applying GenAI and large language models to scientific workflows, such as text mining and code or workflow acceleration, with appropriate data and privacy practices;
• Background in protein structure prediction and analysis, protein engineering (structure-function), and protein-nucleic acid interactions;
• Experience with RNA structure analysis and/or molecular simulation methods (e.g., molecular dynamics);
• Experience with chromatin accessibility and structure analysis (e.g., ATAC-seq) and advanced machine learning approaches for editing-tool optimization;
• Knowledge of DNA repair pathways and their influence on editing outcomes;
• Experience with HPC-scale computing and optimization methods for experimental design, including parallelization and workflow performance tuning.

Employees can expect to be paid a salary between $97,120.00 - $145,680.00. Additional compensation may include a bonus or incentive compensation (if relevant). Additional benefits include health care, vision, dental, retirement, PTO, sick leave, etc.. This salary range is merely an estimate and may vary based on an applicant’s location, market data/ranges, an applicant’s skills and prior relevant experience, certain degrees and certifications, and other relevant factors.

This posting will be available for application until at least September 9, 2026.

To all recruitment agencies: Bayer does not accept unsolicited third party resumes.

Bayer is an Equal Opportunity Employer/Disabled/Veterans

Bayer is committed to providing access and reasonable accommodations in its application process for individuals with disabilities and encourages applicants with disabilities to request any needed accommodation(s) using the contact information below.

Equal Opportunity Employer Statement: Notice for U.S. Visitors: All information on this site is subject to compliance with local rule and regulations as they may vary from time to time and across different geographies, including, without limitation, U.S. Executive Orders.

Bayer is an E-Verify Employer.

Location: Chesterfield

Division: Crop Science

Reference Code: 883986

Contact Us Email: [e-mail]