Formulation Scientist

Integrated Resources, Inc ( IRI ); Lexington (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Integrated Resources, Inc (IRI) is seeking an Associate Research Scientist Contractor in RNAi Formulations within the Non-Viral Delivery group. This role focuses on hands-on RNAi formulation development, biophysical characterization, and supporting oligonucleotides for injectable therapeutics.

Collaboration with cross-functional teams is essential. The position emphasizes rigorous experimentation, high-throughput approaches, and careful documentation to drive developability assessments and

Qualifications

• MS with approximately 3 years of relevant experience, or PhD with 1-3 years in pharmaceutical sciences or related field.
• Hands-on formulation and characterization experience with oligonucleucleoProduct or antibodies/proteins preferred.
• Experience with developability assessments and analytical method development is desirable.

Responsibilities

• Support the development and characterization of preclinical RNAi and oligonucleoProduct formulations.
• Perform hands-on formulation preparation and biophysical characterization.
• Run screening assays for oligonucleoProduct in early discovery and assess stability.
• Contribute to high-throughput and DoE-based formulation optimization.
• Maintain documentation and communicate findings through reports and presentations.

Skills

Lab formulation experience

Analytical characterization

Developability assessments

Education

MS or PhD in pharmaceutical sciences/related

Tools

Automation

Design of Experiments (DoE)

Job description

Shift: Onsite; Monday to Friday, 8:00 AM to 5:00 PM

TOP SKILLS PER MGR:

• 1. Lab experience in formulation of oligonucleoProduct or antibodies for subcutaneous injection
• 2. Hands on analytical characterization of oligonucleoProduct or antibodies/protein
• 3. Experience with developability assessments, including evaluation of parameters like maximum solubility, viscosity, osmolality, limited chemical, and physical stability

Description :

The Associate Research Scientist Contractor, RNAi Formulations, will be based within Non-Viral Delivery (NVD) in Research & Early Development. This is a laboratory-based role focused on hands-on RNAi formulation development, biophysical and analytical characterization, and support of oligonucleoProduct delivery activities for injectable therapeutics.

Relationships

Reports to the US Team Manager for Nucleic Acid Delivery, Formulations and Bioanalysis. Interacts closely with peers and cross-functional partners specializing in non-viral delivery, formulation development, oligonucleoProduct chemistry, stability assays, PK, bioanalysis, Client, and external collaborators.

Essential Functions :

• Support the development and characterization of preclinical RNAi and oligonucleoProduct formulations across portfolio and platform projects.
• Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments.
• Establish and run screening assays for oligonucleoProduct in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, , and stability assessments
• Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
• Support long-term storage and stability evaluations for RNAi conjugates and oligonucleoProduct formulations.
• Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
• Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
• Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
• Thrive in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines.

Qualifications and skills

• MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleoProduct delivery, or a related discipline.
• Hands-on experience with oligonucleoProduct or antibodies/proteins formulation and characterization is strongly preferred.
• Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, , stability, or other developability assessments for complex oligonucleoProduct or antibody/protein formulations.
• Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage.
• Strong experimental planning, documentation, data analysis, and problem-solving skills.
• Excellent verbal and written communication skills, with the ability to work effectively across disciplines and functions.
• Awareness of external trends and advances in RNA delivery, oligonucleoProduct therapeutics, and clinical translation is a plus.
• A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus.