Executive Director, Peptide Macrocycles MedChem

Eli Lilly and Company; Pasadena (CA); On-site; USD 168,000 - 290,000; Full time

Benefits offered by this job

401(k) matching

Pension plan

Vacation benefits

Medical, dental, vision coverage

Job summary

Protomer Technologies, a Lilly subsidiary based in Pasadena, California, seeks an Executive Director - Head of Peptide Macrocycles Medicinal Chemistry to oversee medicinal chemistry and lead optimization for macrocycle programs, advancing hits and leads toward candidate designation.

The role requires proven leadership in drug discovery, strategy development, and cross-functional collaboration to deliver medicinal chemistry that supports portfolio goals and clinical progression.

Qualifications

• PhD in chemistry or synthetic chemistry or peptide chemistry or related field with significant successful drug discovery and development experience.
• Experience leading teams in medicinal chemistry and optimization campaigns expanding programs to candidate designation.
• Deep knowledge of oral macrocycles and macrocyclic peptides.
• Leadership in development of new medicines, including peptide efforts and design of lead optimization strategies.
• Experience with library-based screening technologies and structure-guided optimization.

Responsibilities

• Formulate strategy and execute deep technical development for macrocycle programs.
• Lead molecule engineering efforts and optimization across teams.
• Foster a high-performance, safety-conscious, collaborative environment.

Skills

Leadership

Strategic thinking

Cross-functional collaboration

Molecular design

Team mentorship

Education

PhD in chemistry or synthetic/peptide chemistry

Tools

Computational chemistry

mRNA display

AS/MS screening technologies

Job description

Protomer Technologies, a Lilly subsidiary based in Pasadena, California, seeks an Executive Director - Head of Peptide Macrocycles Medicinal Chemistry to oversee medicinal chemistry and lead optimization for macrocycle programs, advancing hits and leads toward candidate designation.

The role requires proven leadership in drug discovery, strategy development, and cross-functional collaboration to deliver medicinal chemistry that supports portfolio goals and clinical progression.