Executive Director, Peptide Macrocycles Med Chem

BioSpace; Pasadena (CA); On-site; USD 168,000 - 290,000; Full time

Benefits offered by this job

On-site in Pasadena

Competitive compensation

Comprehensive benefits package

Annual bonus eligibility

Job summary

Lilly in Pasadena, California, is seeking an Executive Director - Head of Peptide Macrocycles Medicinal Chemistry to lead the macrocycle discovery and optimization effort. The role demands strategic vision, robust leadership of a multidisciplinary team, and a track record of advancing macrocycle programs toward candidate designation and clinical development.

The successful candidate will guide medicinal chemistry strategy, collaborate across discovery platforms, mentor junior scientists, and

Qualifications

• PhD in chemistry or related field with significant drug discovery experience.
• Proven leadership of medicinal chemistry and optimization campaigns.
• Expertise in oral macrocycles/macrocyclic peptides and related screening tech.

Responsibilities

• Formulate strategy and execute deep technical development for lead optimization and candidate declaration.
• Lead molecule engineering efforts and cross-functional collaboration.
• Mentor junior scientists and manage milestones within Protomer’s portfolio; ensure timely delivery of clinical candidates.

Skills

Leadership

Medicinal chemistry

Macrocycle chemistry

Team management

Strategic planning

Molecule optimization

Computational design/AI in drug design

Education

PhD in chemistry or related field

Job description

Lilly in Pasadena, California, is seeking an Executive Director - Head of Peptide Macrocycles Medicinal Chemistry to lead the macrocycle discovery and optimization effort. The role demands strategic vision, robust leadership of a multidisciplinary team, and a track record of advancing macrocycle programs toward candidate designation and clinical development.

The successful candidate will guide medicinal chemistry strategy, collaborate across discovery platforms, mentor junior scientists, and