Executive Director, Peptide Macrocycles Medicinal Chemistry

100 Eli Lilly and Company; Pasadena (CA); On-site; USD 168,000 - 290,000; Full time

Job summary

Lilly's Protomer Technologies in Pasadena seeks an Executive Director - Head of Peptide Macrocycles Medicinal Chemistry to oversee macrocycle programs, guide optimization, and advance candidates to the clinic. The role demands strategic leadership, hands-on science, and collaboration across a global team.

The candidate will lead the portfolio, mentor junior scientists, and drive translational strategy for oral macrocycles with a proven track record in drug development.

Qualifications

• PhD in chemistry or synthetic/peptide chemistry with drug discovery experience.
• Deep knowledge of oral macrocycles and macrocyclic peptides.
• Proven track record leading teams in medicinal chemistry and optimization campaigns.
• Experience advancing programs to candidate designation and clinical testing.

Responsibilities

• Formulate strategy and execute for deep technical development to accelerate hits to candidate declaration.
• Lead molecule engineering efforts and guide cross-functional teams to delivery.
• Inspire the team, maintain high quality scientific hypotheses, and remove barriers.
• Prioritize safety and foster a proactive safety culture in all activities.

Skills

Leadership

Molecular design

Macrocycle chemistry

Drug discovery

Team management

Education

PhD in chemistry or related field

Job description

Lilly's Protomer Technologies in Pasadena seeks an Executive Director - Head of Peptide Macrocycles Medicinal Chemistry to oversee macrocycle programs, guide optimization, and advance candidates to the clinic. The role demands strategic leadership, hands-on science, and collaboration across a global team.

The candidate will lead the portfolio, mentor junior scientists, and drive translational strategy for oral macrocycles with a proven track record in drug development.