Executive Director - Head of Peptide Macrocycles Medicinal Chemistry

Eli Lilly and Company; Pasadena (CA); Sur place; USD 250 000 - 360 000; Plein temps

Résumé du poste

Scorpion Therapeutics seeks an Executive Director to lead the peptide macrocycles medicinal chemistry program, driving discovery, optimization, and development of oral macrocyclic drugs.

You will oversee medicinal chemistry efforts, mentor scientists, and collaborate with ADME, safety, and PK/PD teams to progress programs from hit to clinic.

Qualifications

• PhD in chemistry or peptide chemistry.
• Extensive oral macrocycle drug discovery experience with molecules advancing to clinical testing.
• Deep expertise in macrocyclic peptides and library screening technologies (e.g., mRNA display, solution-phase, OBOC).
• Experience with structure-guided optimization.

Responsabilités

• Formulate and execute strategic direction for macrocycle programs.
• Oversee medicinal chemistry efforts using peptide chemistry and library-based screening technologies.
• Mentor junior scientists.
• Collaborate cross-functionally with ADME, safety, and PK/PD teams.
• Drive programs from hit identification to candidate nomination and clinic progression.

Connaissances

Macrocycle chemistry

Peptide chemistry

Mentorship

Cross-functional collaboration

Strategic leadership

Formation

PhD in Chemistry

Outils

Computational tools

Description du poste

Role:

Executive Director - Head of Peptide Macrocycles Medicinal Chemistry, leading discovery, optimization, and development of oral macrocyclic drugs.

Responsibilities:

• formulate and execute strategic direction for macrocycle programs;
• oversee medicinal chemistry efforts using peptide chemistry and library-based screening technologies;
• mentor junior scientists;
• collaborate cross-functionally with ADME, safety, and PK/PD teams;
• drive programs from hit identification to candidate nomination and clinic progression.

Requirements:

• PhD in chemistry, synthetic chemistry, or peptide chemistry;
• extensive experience in oral macrocycle drug discovery, with a proven track record of advancing molecules into clinical testing;
• deep expertise in macrocyclic peptides, library screening technologies (e.g., mRNA display, solution-phase, OBOC), and structure-guided optimization.

Preferred:

• familiarity with computational/AI/machine learning tools in drug development;
• experience in peptide or protein therapeutics clinical success.

HighValue:

• oral macrocyclic peptides
• drug discovery and lead optimization
• candidate progression to clinic
• cross-functional collaboration
• strategic leadership
• team development

WorkSetup:

onsite Pasadena, CA; some domestic and international travel expected.