Executive Director, Global Commercial Forecasting

Vertex Pharmaceuticals; Boston (MA); On-site; USD 260,000 - 420,000; Full time

Job summary

Vertex Pharmaceuticals is seeking an Executive Director, Commercial Analytics — Global Forecasting to lead the global forecasting capability across the portfolio, spanning early pipeline, pre-launch, launch, lifecycle, and in-line products.

This senior role owns forecasting standards, governance, and the annual Long-Range Planning process, partnering with Finance, disease leaders, regions, and Manufacturing to align revenue outlook with strategic investments.

Responsibilities

• Lead the Global Forecasting organization and capability agenda across pipeline, pre-launch, launch, lifecycle, and in-line disease areas.
• Own the integrated global revenue outlook for the Vertex portfolio, including underlying market, patient, access, competitive, clinical, regulatory, pricing, and commercial assumptions.
• Co-lead the annual LRP revenue forecasting process with GCS leadership and Corporate Finance, establishing the process, calendar, deliverables, governance, and executive decision points.
• Integrate disease-area forecasts into a coherent portfolio view and clearly communicate value drivers, sensitivities, risks, opportunities, uncertainties, and implications for investment.
• Establish enterprise forecasting standards, including model architecture, assumptions, scenario frameworks, documentation, quality control, version management, review expectations, and approval governance.
• Create a connected forecasting model across global and regional processes, ensuring near-term in-line forecasts and longer-range global forecasts use aligned assumptions, transparent transitions, and clearly defined accountabilities.
• Partner with Manufacturing and Supply Chain to translate commercial forecasts into demand and capacity-planning inputs, including appropriate scenarios, ranges, timing, and updates at material inflection points.
• Ensure forecasts are refreshed when material clinical, regulatory, competitive, access, market, or supply information changes the outlook or the decisions the forecast must support.
• Build base, upside, downside, and alternative scenarios that quantify key uncertainties and enable strategic, portfolio, launch, capital-allocation, and supply decisions.
• Ensure forecasts integrate evidence from Market Research, Decision Science, Competitive Intelligence, epidemiology, HEOR, Value & Access, Medical, Development, and external data sources.
• Provide objective forecasting leadership to disease teams and senior governance forums, pressure-testing assumptions and translating complex outputs into clear recommendations.
• Establish fit-for-purpose forecasting approaches across different lifecycle stages, from early opportunity assessments and commercial due diligence through launch and mature in-line products.
• Build scalable forecasting tools, templates, data structures, and reporting mechanisms that improve transparency, comparability, agility, and reuse across the portfolio.
• Select and manage external forecasting partners where specialized capacity is needed while maintaining internal ownership of methodologies, assumptions, interpretation, and quality.
• Build, develop, and retain a high-performing global forecasting team with strong technical depth, portfolio perspective, business judgment, and executive communication capability.
• Measure forecast performance, process effectiveness, stakeholder confidence, and decision impact; use lessons learned to continuously improve models, standards, and ways of working.

Job description

Vertex Pharmaceuticals is seeking an Executive Director, Commercial Analytics — Global Forecasting to lead the global forecasting capability across the portfolio, spanning early pipeline, pre-launch, launch, lifecycle, and in-line products.

This senior role owns forecasting standards, governance, and the annual Long-Range Planning process, partnering with Finance, disease leaders, regions, and Manufacturing to align revenue outlook with strategic investments.